Measurement of aortic valve calcification using multislice computed tomography: correlation with haemodynamic severity of aortic stenosis and clinical implication for patients with low ejection fraction
Measurement of aortic valve calcification using multislice computed tomography: correlation with haemodynamic severity of aortic stenosis and clinical implication for patients with low ejection fraction
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DOI：
10.1136/hrt.2010.198853
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发表时间：
2011-05-01
期刊：
影响因子：
5.7
通讯作者：
Messika-Zeitoun, David
中科院分区：
文献类型：
--
作者：
Cueff, Caroline;Serfaty, Jean-Michel;Messika-Zeitoun, David
背景电子束计算机断层扫描（EBCT）测量主动脉瓣钙化程度（AVC）是经胸超声心动图（TTE）评估主动脉瓣狭窄（AS）严重程度的准确和补充方法。EBCT获得的AVC阈值是否可以外推到多层计算机断层扫描（MSCT）尚不清楚，AVC诊断价值在低射血分数（EF）患者从来没有具体evaluated.Methods轻度至重度AS患者进行前瞻性1周内MSCT和TTE。重度AS定义为主动脉瓣面积（AVA）小于1 cm（2）。在179例EF大于40%的患者（验证集）中，评价了AVC和AVA之间的关系。然后在第二个子集（测试集）中评估了诊断严重AS的最佳AVC阈值，该子集包括49例低EF患者（
Background Measurement of the degree of aortic valve calcification (AVC) using electron beam computed tomography (EBCT) is an accurate and complementary method to transthoracic echocardiography (TTE) for assessment of the severity of aortic stenosis (AS). Whether threshold values of AVC obtained with EBCT could be extrapolated to multislice computed tomography (MSCT) was unclear and AVC diagnostic value in patients with low ejection fraction (EF) has never been specifically evaluated.Methods Patients with mild to severe AS underwent prospectively within 1 week MSCT and TTE. Severe AS was defined as an aortic valve area (AVA) of less than 1 cm(2). In 179 patients with EF greater than 40% (validation set), the relationship between AVC and AVA was evaluated. The best threshold of AVC for the diagnosis of severe AS was then evaluated in a second subset (testing set) of 49 patients with low EF (