Oxidative stress in obstructive sleep apnea
Oxidative stress in obstructive sleep apnea
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DOI：
10.1378/chest.127.5.1674
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发表时间：
2005-05-01
期刊：
影响因子：
9.6
通讯作者：
Kimura, H
中科院分区：
文献类型：
--
作者：
Yamauchi, M;Nakano, H;Kimura, H
研究目的：探讨阻塞性睡眠呼吸暂停（OSA）的严重程度与氧化应激之间的关系，氧化应激在心血管疾病的发病机制中起着重要作用，并阐明促成这种关系的因素。设计：横断面研究。参与者：共有128名连续受试者转介到我院睡眠实验室进行OSA的筛查或治疗。干预：不适用。测量：通过多导睡眠图评估睡眠呼吸障碍的严重程度。我们测量了8-羟基-2 '-脱氧鸟苷（S-OHdG）的尿排泄，作为体内氧化应激的参数。结果：70例非重度OSA（AHI < 30），58例重度OSA（AHI>= 30），重度OSA组尿8-OHdG排泄量显著高于对照组（P = 0.03）。此外，尿8-OHdG排泄与睡眠呼吸障碍的参数显著相关，包括AHI、呼吸暂停指数、氧饱和度下降指数（ODI）、氧饱和度<90%的持续时间和呼吸觉醒指数。然而，只有ODI与尿S-OHdG排泄调整后的混杂因素，被认为是相关的氧化stress.Conclusions：OSA的严重程度是独立相关的氧化应激。在各种睡眠呼吸障碍参数中，ODI与氧化应激的关系最为密切。
Study objectives: To investigate the relationship between the severity of obstructive sleep apnea (OSA) and oxidative stress, which plays an important role in the pathogenesis of cardiovascular disease, and to elucidate the factors contributing to this relationship.Design: Cross-sectional study.Participants: A total of 128 consecutive subjects referred to the sleep laboratory of our hospital for screening or treatment of OSA.Interventions: Not applicable.Measurements: The severity of sleep-disordered breathing was evaluated by polysomnography. We measured urinary excretion of 8-hydroxy-2'-deoxyguanosine (S-OHdG) as an in vivo parameter of oxidative stress. Known risk factors for oxidative stress (age, obesity, smoking, hyperlip-idemia, hypertension, and diabetes mellitus) were also investigated.Results: Seventy subjects had nonsevere OSA (an apnea-hypopnea index [AHI] < 30), and 58 subjects had severe OSA (AHI >= 30), Urinary 8-OHdG excretion was significantly higher in the severe OSA group (p = 0.03). Furthermore, urinary 8-OHdG excretion was significantly correlated with parameters of sleep-disordered breathing, including AHI, the apnea index, the oxygen desaturation index (ODI), the duration of oxygen saturation < 90%, and the respiratory arousal index. However, only ODI was significantly correlated with urinary S-OHdG excretion after adjustment for confounding factors that are considered to be related to oxidative stress.Conclusions: The severity of OSA is independently associated with oxidative stress. Among various sleep-disordered breathing parameters, ODI is most closely related to oxidative stress.