Efficacy of a newly developed bioabsorbable pancreatic clip for distal pancreatectomy in swine
Efficacy of a newly developed bioabsorbable pancreatic clip for distal pancreatectomy in swine
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DOI：
10.1007/s00595-021-02435-x
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发表时间：
2022-01-12
期刊：
影响因子：
2.5
通讯作者：
Baba, Hideo
中科院分区：
文献类型：
--
作者：
Yamashita, Yo-ichi;Yamao, Takanobu;Baba, Hideo
目的目前，20%的患者在远端胰腺切除术(DP)后出现了临床相关的术后胰瘘(POPF)。方法我们研制了一种新型的生物可吸收胰腺夹(Biopac)，它由聚己内酯制成，在阻断胰腺残端时不会挤压胰腺实质。我们在猪DP模型中证实了这种Biopac的有效性，并将其与线性订书器(Readence(R))进行了比较。结果断头后1个月处死猪。在Biopac组，所有的猪(n=3)在没有POPF的情况下存活良好。强化(R)组(n=2)，1只猪术后7d早期死亡，淀粉酶C级(43700U/L)，另1只在烫伤后生化渗漏(淀粉酶3725U/L)存活至1个月。在病理上，Biopac使主胰管和胰腺实质闭合良好。结论新研制的Biopac在猪DP模型中是有效的。
Purpose At present, >= 20% of patients experience clinically relevant postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP). Methods We developed a new bioabsorbable pancreatic clip (BioPaC) made of polycaprolactone that does not crush the pancreatic parenchyma during occlusion of the pancreatic stump. We confirmed the efficacy of this BioPac in a porcine DP model and compared it to a linear stapling device (Reinforce (R)). Results Pigs were killed at 1 month after DP. In the BioPaC group, all swine (n = 3) survived well without POPF. In the Reinforce (R) group (n = 2), one pig died early at postoperative day 7 with Grade C POPF (amylase 43 700 U/l), and the other survived until 1 month at scarification with biochemical leakage of POPF (amylase 3 725 U/l). Pathologically, the main pancreatic duct and pancreatic parenchyma were well closed by BioPaC. Conclusion The newly developed BioPaC is effective in a porcine DP model.