Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors
Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors
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DOI：
10.1063/1.4875903
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发表时间：
2014-05-12
影响因子：
4
通讯作者：
Chen, Ray T.
中科院分区：
文献类型：
--
作者：
Chakravarty, Swapnajit;Hosseini, Amir;Chen, Ray T.
我们分析了芯片集成谐振微腔器件的品质因数、填充分数和群指数对体化学传感检测限和生物传感中最小可检测生物分子浓度的贡献。我们分析了分析物吸光度的贡献，以及温度和光谱噪声。二维光子晶体中的慢光提供了将检测极限显著降低到1 × 10（-7）RIU（折射率单位）以下的机会，这可以使高灵敏度传感器在不同的应用领域成为可能。我们证明实验检测浓度为1 fM（67 fg/ml）的生物素和抗生物素蛋白之间的结合，最低的报告日期。(C)2014 AIP Publishing LLC.
We analyze the contributions of quality factor, fill fraction, and group index of chip-integrated resonance microcavity devices, to the detection limit for bulk chemical sensing and the minimum detectable biomolecule concentration in biosensing. We analyze the contributions from analyte absorbance, as well as from temperature and spectral noise. Slow light in two-dimensional photonic crystals provide opportunities for significant reduction of the detection limit below 1 x 10(-7) RIU (refractive index unit) which can enable highly sensitive sensors in diverse application areas. We demonstrate experimentally detected concentration of 1 fM (67 fg/ml) for the binding between biotin and avidin, the lowest reported till date. (C) 2014 AIP Publishing LLC.