Quantitative trait loci on chromosomes 10 and 11 influencing mandible size of SMXA RI mouse strains
Quantitative trait loci on chromosomes 10 and 11 influencing mandible size of SMXA RI mouse strains
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DOI：
10.1177/154405910208100714
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发表时间：
2002-07-01
影响因子：
7.6
通讯作者：
Maeda, T
中科院分区：
文献类型：
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作者：
Dohmoto, A;Shimizu, K;Maeda, T
在颌面骨生长终止之前预测下颌骨的大小在儿童牙科学以及遗传分析所需的预测中是必不可少的。在这里，数量性状基因座（QTL）分析被用来检测染色体区域负责下颌骨长度之间的门顿和角在SMXA重组近交系小鼠。在第10号染色体距着丝粒60 cM的区域，比值分数的对数显示高于提示水平。在11号染色体13 cM和16 cM区域附近检测到两个显着的QTL。当标记Hba与D11Mit163和D10Mit70与D10Mit136之间的区域分别指示来自A/J和SM/J等位基因的基因型时，从对应于这些QTL的位点的基因型分析显示大下颌。这些结果表明，负责下颌骨长度的主基因位于这些区域。
Predicting the mandible size before the termination of growth of the maxillofacial bones is essential in pedodontics as well as for the predictions needed for genetic analysis. Here, Quantitative Trait Locus (QTL) analysis was used to detect the chromosomal regions responsible for the mandible length between the menton and gonion in an SMXA recombinant inbred strain of mice. Around the region 60 cM from the centromere in chromosome 10, the logarithm of the odds score showed a higher than suggestive level. Around the regions 13 cM and 16 cM in chromosome 11, two significant QTLs were detected. Analysis of genotypes from loci corresponding to those QTLs revealed a large mandible when the region between the markers Hba and D11Mit163 and D10Mit70 and D10Mit136 indicated the genotype from the A/J and SM/J alleles, respectively. These results suggest that the major gene(s) responsible for mandible length are located in these regions.