Relationship Between Thin Cap Fibroatheroma Identified by Virtual Histology and Angioscopic Yellow Plaque in Quantitative Analysis With Colorimetry
Relationship Between Thin Cap Fibroatheroma Identified by Virtual Histology and Angioscopic Yellow Plaque in Quantitative Analysis With Colorimetry
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DOI：
10.1253/circj.cj-08-0762
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发表时间：
2009-03-01
影响因子：
3.3
通讯作者：
Mizuno, Kyoichi
中科院分区：
文献类型：
--
作者：
Yamamoto, Masanori;Takano, Masamichi;Mizuno, Kyoichi
背景：薄帽纤维粥样硬化（TCFA）被认为是一种易损斑块。虚拟组织学-血管内超声（VH-IVUS）可以精确识别体内TCFA。L*a*b*色空间定量比色法检测血管镜上强黄色斑块与组织学TCFA相对应；特别是，b*值bbb23的斑块表示动脉粥样硬化，纤维帽厚度为斑块面积的10%，没有覆盖纤维组织，血管镜TCFA为b*值bbb23的斑块。血管镜下TCFA的频率在VH-TCFA组高于vh -非TCFA组（74% vs 23%， P=0.0002）。此外，黄色强度（b*值）与VH-IVUS斑块分类显著相关。以血管镜检测TCFA为金标准，VH-IVUS检测TCFA的敏感性为68%，特异性为81%，准确性为75%。结论：通过比色法定量分析，VH-TCFA与血管镜TCFA密切相关。（Circ J 2009; 73: 497-502）
Background: Thin cap fibroatheroma (TCFA) is considered to be a vulnerable plaque. Virtual Histology-intravascular ultrasound (VH-IVUS) can precisely identify TCFA in vivo. Intense yellow plaque on angioscopy determined by quantitative colorimetry with L*a*b* color space corresponds with histological TCFA; in particular, a plaque of color b* value >23 indicates an atheroma with a fibrous cap thickness 10% of plaque area without overlying fibrous tissue, and angioscopic TCFA was a plaque with b* value >23. The frequency of angioscopic TCFA was higher in the VH-TCFA group than in the VH-non-TCFA group (74% vs 23%, P=0.0002). Moreover, yellow color intensity (b* value) significantly correlated with plaque classification on VH-IVUS. When TCFA detected with angioscopy was used as the gold standard, the sensitivity, specificity, and accuracy for TCFA with VH-IVUS was 68%, 81%, and 75%, respectively.Conclusions: VH-TCFA strongly correlated with angioscopic TCFA determined by a quantitative analysis with colorimetry. (Circ J 2009; 73: 497-502)