MAPK Activated Protein Kinase 3 Is a Prognostic-Related Biomarker and Associated With Immune Infiltrates in Glioma.
MAPK Activated Protein Kinase 3 Is a Prognostic-Related Biomarker and Associated With Immune Infiltrates in Glioma.
复制标题
DOI：
10.3389/fonc.2021.793025
复制
发表时间：
2021
影响因子：
4.7
通讯作者：
Cao H
中科院分区：
文献类型：
--
作者：
Ren J;Sun J;Li M;Zhang Z;Yang D;Cao H
神经胶质瘤是最常见的原发性脑肿瘤，发病率和死亡率都很高。MAPK活化蛋白激酶3 （MAPKAPK3/MK3）是一种丝氨酸/苏氨酸蛋白激酶，调节多种细胞反应和基因表达。然而，MK3在胶质瘤的肿瘤进展、预后和免疫中的作用尚不清楚。在这里，我们确定了MK3的表达和预后价值。利用现有数据库，采用生物化学方法和生物信息学方法进一步分析MK3表达与免疫浸润的相关性。我们发现MK3在胶质瘤中异常上调。此外，MK3的高表达与胶质瘤患者较差的临床病理特征密切相关。重要的是，MK3的表达与胶质瘤患者的预后呈负相关。在机制上，我们证明了MK3的相关基因主要富集在调节肿瘤免疫反应的途径中。MK3水平与肿瘤浸润性免疫细胞显著相关，与胶质瘤中大多数肿瘤免疫抑制剂、趋化因子和趋化因子受体呈正相关。因此，这些发现提示了MK3在预后中的新作用，并将MK3定义为神经胶质瘤免疫治疗的一个有希望的靶点。
Glioma is the most common primary brain tumor that causes significant morbidity and mortality. MAPK activated protein kinase 3 (MAPKAPK3/MK3) is a serine/threonine protein kinase regulating various cellular responses and gene expression. However, the role of MK3 in tumor progress, prognosis, and immunity for glioma remains unclear. Here, we determined the expression and prognostic values of MK3. We further analyzed the correlation of MK3 expression with immune infiltrations by using the biochemical methods and bioinformatic approaches with available databases. We find that MK3 is aberrantly upregulated in glioma. In addition, the higher MK3 expression is closely linked to the poor clinicopathologic features of glioma patients. Importantly, MK3 expression is negatively correlated with the prognosis of patients with glioma. Mechanistically, we demonstrated that the correlated genes of MK3 were mainly enriched in pathways that regulate tumor immune responses. The MK3 level was significantly associated with tumor-infiltrating immune cells and positively correlated with the majority of tumor immunoinhibitors, chemokines, and chemokine receptors in glioma. Thus, these findings suggest the novel prognostic roles of MK3 and define MK3 as a promising target for glioma immunotherapy.
登录
查看更多内容
影响因子：
13.3
作者：
Iser, Isabele C.;Pereira, Mariana B.;Wink, Marcia R.
通讯作者：
Wink, Marcia R.
鉴定免疫相关基因签名以改善结直肠癌患者的预后预测。
影响因子：
3.7
作者：
Dai S;Xu S;Ye Y;Ding K
通讯作者：
Ding K
DOI：
10.1126/science.aao4750
发表时间：
2018-04-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Filbin MG;Tirosh I;Hovestadt V;Shaw ML;Escalante LE;Mathewson ND;Neftel C;Frank N;Pelton K;Hebert CM;Haberler C;Yizhak K;Gojo J;Egervari K;Mount C;van Galen P;Bonal DM;Nguyen QD;Beck A;Sinai C;Czech T;Dorfer C;Goumnerova L;Lavarino C;Carcaboso AM;Mora J;Mylvaganam R;Luo CC;Peyrl A;Popović M;Azizi A;Batchelor TT;Frosch MP;Martinez-Lage M;Kieran MW;Bandopadhayay P;Beroukhim R;Fritsch G;Getz G;Rozenblatt-Rosen O;Wucherpfennig KW;Louis DN;Monje M;Slavc I;Ligon KL;Golub TR;Regev A;Bernstein BE;Suvà ML
通讯作者：
Suvà ML
影响因子：
4.4
作者：
Drube, Sebastian;Kraft, Florian;Kamradt, Thomas
通讯作者：
Kamradt, Thomas
影响因子：
15.9
作者：
Ostrom, Quinn T.;Gittleman, Haley;Barnholtz-Sloan, Jill S.
通讯作者：
Barnholtz-Sloan, Jill S.