Muscle preservation using an implantable electrical system after nerve injury and repair
Muscle preservation using an implantable electrical system after nerve injury and repair
复制标题
神经损伤和修复后使用植入式电气系统保存肌肉
作者：
S. Nicolaidis;H. Williams
在三种动物模型的一系列实验室实验中，已经清楚地显示了在神经损伤和修复后对失神经肌肉进行连续电刺激的价值。该实验背景显示出改善的肌肉保护和更好的功能结果，并演变为一项临床研究，其中包括15例上肢周围神经损伤患者，3例臂丛神经损伤患者和3例面神经麻痹患者。使用该植入式系统获得了改善的功能结果，这与动物实验所获得的结果相似。所有患者均接受了127至346天的肌肉刺激。结果分析表明，临床检查和肌电图研究的神经再生令人满意。功能性肌肉分析因患者而异，但每个患者都有令人满意的极好恢复。本研究的结果清楚地表明了在神经损伤和修复后使用植入式电气系统进行连续肌肉刺激的受益，表明该项目可扩展至更大的患者队列。© 2001 Wiley利斯公司显微外科21：241-247 2001
The value of continuous electrical stimulation of denervated muscles after nerve injury and repair has been clearly shown in a series of laboratory experiments in three animal models. This experimental background, which showed improved muscle preservation and better functional results, evolved into a clinical study that included 15 patients with peripheral nerve injuries in the upper extremities, 3 patients with brachial plexus injuries, and three patients with facial nerve paralysis. Improved functional results were obtained using this implantable system, which were similar to those achieved with the animal experiments. All patients had muscle stimulation for extended periods ranging from 127 to 346 days. Analysis of the results showed satisfactory nerve regeneration on clinical examination and with electromyographic studies. Functional muscle analysis varied somewhat from patient to patient, but every patient had a satisfactory to excellent recovery. The results from this study have clearly shown the benefits of continuous muscle stimulation using an implantable electrical system after nerve injury and repair expansion of the project to a larger patient cohort is indicated. © 2001 Wiley‐Liss, Inc. MICROSURGERY 21:241–247 2001