Adjuvant (Postoperative) Therapy for Esophageal Cancer
Adjuvant (Postoperative) Therapy for Esophageal Cancer
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DOI：
10.1016/j.thorsurg.2013.07.008
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发表时间：
2013-11-01
影响因子：
2.1
通讯作者：
Ilson, David H.
中科院分区：
文献类型：
--
作者：
Ku, Geoffrey Y.;Ilson, David H.
本文重点介绍局部晚期食管癌的辅助（术后）策略。总结了已完成的食管和胃食管 (GE) 交界处局部晚期腺癌和鳞状细胞癌 (SCC) 术后治疗 III 期试验的结果。与单独手术治疗食管和胃食管交界处腺癌相比，多种术后和围手术期策略已被证明可将生存率提高约 15%。另一方面，所有经过验证的可切除鳞状细胞癌策略都涉及术前治疗，而针对鳞状细胞癌的术后治疗还没有经过验证的策略。
This article focuses on adjuvant (postoperative) strategies for locally advanced esophageal cancers. Results of completed phase III trials of postoperative therapy for locally advanced adenocarcinomas and squamous cell carcinomas (SCCs) of the esophagus and gastroesophageal (GE) junction are summarized. Several postoperative and perioperative strategies have been shown to improve survival by approximately 15% when compared with surgery alone for adenocarcinomas of the esophagus and GE junction. On the other hand, all proven strategies for resectable SCCs involve preoperative treatment, and there are no validated strategies for the postoperative treatment of SCC.