Progressive glomerular injury after limited renal infarction in the rat.
Progressive glomerular injury after limited renal infarction in the rat.
复制标题
大鼠局限性肾梗死后进行性肾小球损伤。
DOI：
10.1152/ajprenal.1988.254.6.f856
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Rennke,HG
中科院分区：
文献类型：
--
作者：
Meyer,TW;Rennke,HG
Wistar慕尼黑大鼠进行部分肾消融与完整的大鼠进行了比较。第1组大鼠进行双侧节段性梗死的40%，他们的总肾质量。第2组大鼠行单侧肾切除术。第3组为假手术组。术后28周行显微穿刺和形态学检查。在第1组中，尽管肾单位数量仅减少40%，肾小球滤过率（GFR）仅降低10%，但肾小球毛细血管压升高7 mmHg，全身血压升高31 mmHg。进行性蛋白尿和节段性肾小球硬化与该组肾小球毛细血管压力升高有关。在第2组中，单肾单位肾小球滤过率（SNGFR）高于第1组，但全身和肾小球毛细血管压力保持正常。第2组大鼠发生明显少于第1组大鼠的蛋白尿和肾小球硬化，尽管更明显的残余肾单位超滤。这些研究支持了肾小球高血压是导致残余肾小球损伤的主要血流动力学紊乱的观点，并表明毛细血管高血压可以启动残余肾小球损伤，即使大部分肾脏质量保持完整。
Wistar Munich rats subjected to partial renal ablation were compared with intact rats. Group 1 rats were subjected to bilateral segmental infarction of 40% of their total renal mass. Group 2 rats underwent uninephrectomy. Group 3 rats underwent sham operation. Micropuncture and morphological studies were performed in each group at 28 wk after operation. In group 1, glomerular capillary pressure was elevated by 7 mmHg and systemic blood pressure was elevated by 31 mmHg despite reduction of nephron number by only 40% and reduction of glomerular filtration rate (GFR) by only 10%. Progressive albuminuria and segmental glomerular sclerosis were associated with elevation of glomerular capillary pressure in this group. In group 2, single-nephron glomerular filtration rate (SNGFR) was higher than in group 1, but systemic and glomerular capillary pressure remained normal. Group 2 rats developed markedly less albuminuria and glomerular sclerosis than group 1 rats despite more pronounced remnant nephron hyperfiltration. These studies support the view that glomerular hypertension is the major hemodynamic derangement contributing to remnant glomerular injury and show that capillary hypertension can initiate remnant glomerular injury even when the majority of the renal mass remains intact.