Significance of Interleukin-6 in Papillary Thyroid Carcinoma.
Significance of Interleukin-6 in Papillary Thyroid Carcinoma.
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DOI：
10.1155/2016/6178921
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发表时间：
2016
影响因子：
2.1
通讯作者：
Ghosh NR
中科院分区：
文献类型：
--
作者：
Kobawala TP;Trivedi TI;Gajjar KK;Patel DH;Patel GH;Ghosh NR
本研究旨在通过检测IL-6在甲状腺乳头状癌中的循环水平、肿瘤蛋白和mRNA表达，揭示IL-6在甲状腺乳头状癌中的意义。与健康人相比，良性甲状腺疾病和PTC患者血清IL-6明显升高。此外，与良性甲状腺疾病患者相比，PTC患者的水平明显更高。ROC曲线也证实了血清IL-6在健康个体与良性甲状腺疾病和PTC患者之间具有良好的区分功效。循环IL-6与PTC患者较差的总生存率显著相关。与良性甲状腺疾病患者相比，PTC患者IL-6免疫反应性明显高。PTC患者原发肿瘤组织中IL-6 mRNA的表达也明显高于邻近正常组织。循环和组织水平IL-6蛋白表达与PTC患者疾病侵袭性相关。此外，在PTC患者原发肿瘤中IL-6蛋白与mRNA表达呈显著正相关。总之，IL-6在甲状腺癌的进展中具有重要的作用。因此靶向IL-6信号可以帮助甲状腺癌患者的临床治疗。
This study sought to reveal the significance of IL-6 in papillary thyroid carcinoma by determining its circulating levels, tumoral protein, and mRNA expressions. As compared to the healthy individuals, serum IL-6 was significantly higher in patients with benign thyroid diseases and PTC. Further, its level was significantly higher in PTC patients as compared to patients with benign thyroid diseases. ROC curves also confirmed a good discriminatory efficacy of serum IL-6 between healthy individuals and patients with benign thyroid diseases and PTC. The circulating IL-6 was significantly associated with poor overall survival in PTC patients. IL-6 immunoreactivity was significantly high in PTC patients as compared to the benign thyroid disease patients. Significantly higher IL-6 mRNA expression was also observed in the primary tumour tissues of PTC patients than the adjacent normal tissues. The protein expression of IL-6 at both the circulating and tissue level correlated with disease aggressiveness in PTC patients. Moreover, a significant positive correlation was observed between the IL-6 protein and mRNA expression in the primary tumours of PTC patients. Finally in conclusion, IL-6 has an important role in thyroid cancer progression. Thus targeting IL-6 signalling can help in clinical management of thyroid carcinoma patients.