Sorting through the extensive and confusing roles of sortilin in metabolic disease.
Sorting through the extensive and confusing roles of sortilin in metabolic disease.
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DOI：
10.1016/j.jlr.2022.100243
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发表时间：
2022-08
影响因子：
6.5
通讯作者：
Attie, Alan D.
中科院分区：
文献类型：
--
作者：
Mitok, Kelly A.;Keller, Mark P.;Attie, Alan D.
关键词：
Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure capable of binding more than 50 proteins, covering a wide range of biological functions including lipid and lipoprotein metabolism, neuronal growth and death, inflammation, and lysosomal degradation. Sortilin has a complex cellular trafficking itinerary, where it functions as a receptor in the trans-Golgi network, endosomes, secretory vesicles, multivesicular bodies, and at the cell surface. In addition, sortilin is associated with hypercholesterolemia, Alzheimer’s disease, prion diseases, Parkinson’s disease, and inflammation syndromes. The 1p13.3 locus containing SORT1, the gene encoding sortilin, carries the strongest association with LDL-C of all loci in human genome-wide association studies. However, the mechanism by which sortilin influences LDL-C is unclear. Here, we review the role sortilin plays in cardiovascular and metabolic diseases and describe in detail the large and often contradictory literature on the role of sortilin in the regulation of LDL-C levels.
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影响因子：
20.1
作者：
Amengual J;Guo L;Strong A;Madrigal-Matute J;Wang H;Kaushik S;Brodsky JL;Rader DJ;Cuervo AM;Fisher EA
通讯作者：
Fisher EA
DOI：
10.1016/j.bbrc.2016.07.096
发表时间：
2016-09-16
影响因子：
3.1
作者：
Sparks, Robert P.;Guida, Wayne C.;Sowden, Mark P.;Jenkins, Jermaine L.;Starr, Matthew L.;Fratti, Rutilio A.;Sparks, Charles E.;Sparks, Janet D.
通讯作者：
Sparks, Janet D.
影响因子：
39.3
作者：
Boren, Jan;Chapman, M. John;Ginsberg, Henry N.
通讯作者：
Ginsberg, Henry N.
影响因子：
7.6
作者：
Bai, Yin-Yin;Ruan, Chun-Sheng;Zhou, Xin-Fu
通讯作者：
Zhou, Xin-Fu
影响因子：
3.4
作者：
Al-Shawi, Raya;Hafner, Angela;Cowen, Timothy
通讯作者：
Cowen, Timothy