Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage 'in cellulo'
Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage 'in cellulo'
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DOI：
10.1039/b418964g
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发表时间：
2005-01-01
影响因子：
3.2
通讯作者：
Peacock, RD
中科院分区：
文献类型：
--
作者：
Poole, RA;Bobba, G;Peacock, RD
本文报道了基于环大环的非齿状配体的一系列阳离子、中性和阴离子铕和铽配合物的合成和光物理表征。每个配合物包含四氮三苯部分，在充气水介质中，总的绝对发射量子产率在15 - 40%的范围内。镧系元素激发态的动态猝灭发生在富电子供体，如碘化物、抗坏血酸盐和铀酸盐，并提出了涉及电子转移过程的机制解释。阳离子镧系复合物被N1H/ 3T3细胞吸收，并倾向于定位于细胞核内。
The synthesis and photophysical characterisation are reported of a series of cationic, neutral and anionic europium and terbium complexes based on structurally related, nonadentate ligands based on the cyclen macrocycle. Each complex incorporates a tetraazatriphenylene moiety and overall absolute emission quantum yields are in the range 15 - 40% in aerated aqueous media. Dynamic quenching of the lanthanide excited state occurs with electron-rich donors, e. g. iodide, ascorbate and urate, and a mechanistic interpretation is put forward involving an electron transfer process. The cationic lanthanide complexes are taken up by N1H/ 3T3 cells and tend to localise inside the cell nucleus.