Molecular mediators of mesenchymal stem cell biology.
Molecular mediators of mesenchymal stem cell biology.
复制标题
DOI：
10.1016/b978-0-12-386015-6.00023-8
复制
发表时间：
2011
影响因子：
--
通讯作者：
Young PP
中科院分区：
文献类型：
--
作者：
Alfaro MP;Saraswati S;Young PP
间充质干细胞（MSC）具有自我更新和分化成多个谱系的能力，使其成为干细胞治疗的合适候选者。尽管 MSC 在临床前模型中取得了相当大的成功，但在临床环境中取得的成功却有限。面临的一个主要障碍是植入后受损组织中间充质干细胞的存活率低。为了增强 MSC 的修复特性，了解调节 MSC 存活和自我更新的分子信号至关重要。这篇综述吸收了 MSC 的特征信息，并提到了它们在心肌梗塞治疗中的应用。此外，我们在此尝试收集有关规范 Wnt 和 BMP 信号传导在调节 MSC 自我更新、增殖、分化和存活潜力中的作用的相关已发表信息。
Mesenchymal stem cells (MSCs) have the ability to self-renew and differentiate into multiple lineages making them an appropriate candidate for stem cell therapy. In spite of achieving considerable success in preclinical models, limited success has been achieved in clinical settings with MSCs. A major impediment that is faced is low survival of MSCs in injured tissues following implantation. In order to enhance the reparative properties of MSCs, it is vital to understand the molecular signals that regulate MSC survival and self-renewal. This review assimilates information that characterizes MSCs and mentions their utilization in myocardial infarction therapy. Additionally, our attempt herein is to gather pertinent published information regarding the role of canonical Wnt and BMP signaling in regulating the potential of MSCs to self-renew, proliferate, differentiate, and survive.