Mapping of the MYCL2 processed gene to Xq22-23 and identification of an additional L MYC-related sequence in Xq27.2.
Mapping of the MYCL2 processed gene to Xq22-23 and identification of an additional L MYC-related sequence in Xq27.2.
复制标题
将 MYCL2 加工基因映射到 Xq22-23，并鉴定 Xq27.2 中的额外 L MYC 相关序列。
DOI：
10.1016/s0014-5793(99)00243-4
复制
发表时间：
1999
期刊：
影响因子：
3.5
通讯作者：
Zucchi,I
中科院分区：
文献类型：
--
作者：
Redolfi,E;Pizzuti,A;DiBacco,A;Susani,L;Labella,T;Affer,M;Montagna,C;Reinbold,R;Mumm,S;Vezzoni,P;Zucchi,I
我们在这里报告了从X染色体q27.2区域鉴定出的人类基因组序列，该序列与L-MYC原癌基因具有高度同源性。该序列不是MYCL 2同源序列，先前由Morton等人定位于X染色体的长臂q22-qter，当我们使用包含携带人类X染色体不同部分的杂交DNA组合的面板将MYCL 2加工基因定位在Xq 22 - 23中时。基于计算机分析，MYC样序列（MYCL 3）与MYCL 1基因外显子3的一部分具有98.2%的同一性，并定位于DXS 312和DXS 292基因座之间的Xq27.2区域。
We report here the identification of a human genomic sequence from the q27.2 region of the X chromosome which shows a high homology to the L‐MYC proto‐oncogene. This sequence is not the MYCL2 homology, previously mapped to the long arm of the X chromosome at q22‐qter by Morton et al., as we located the MYCL2‐processed gene in Xq22‐23, using a panel containing a combination of hybrid DNA carrying different portions of the human X chromosome. Based on computer analysis, the MYC‐like sequence (MYCL3) is 98.2% identical to a portion of exon 3 of the MYCL1 gene and maps to the Xq27.2 region, between the DXS312 and DXS292 loci.