The relationships between the amount of spared tissue, percent signal change, and accuracy in semantic processing in aphasia.
The relationships between the amount of spared tissue, percent signal change, and accuracy in semantic processing in aphasia.
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DOI：
10.1016/j.neuropsychologia.2015.10.019
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发表时间：
2016-04
期刊：
影响因子：
2.6
通讯作者：
Kiran S
中科院分区：
文献类型：
--
作者：
Sims JA;Kapse K;Glynn P;Sandberg C;Tripodis Y;Kiran S
失语症的康复，即脑血管事件(中风)后的语言丧失，是一个涉及左右半球的复杂过程。在我们的研究中，我们从功能磁共振成像(FMRI)数据中分析了语义加工行为数据、病变大小和位置以及功能百分比信号变化之间的关系。本研究包括14名慢性恢复期失语症患者(中风后6个月或以上)和8名健康对照组，他们执行语义加工任务，以确定一个书面语义特征是否与图片匹配，或者两个书面单词是否相关。使用感兴趣区(ROI)分析，我们发现左侧额下回盖部和三角部的信号变化百分比，尽管受到了显著的损害，但是唯一与行为准确性相关的区域。此外，LIFG、LMTG和AG/SMG损伤越严重，双侧额上回、额中回和前扣带回的信号变化百分比越高，这表明这些区域在传统语言区受损的情况下似乎起到了辅助网络的作用。与黄体生成素与RH感兴趣区之间和内部的激活主要呈正相关的对照组相比，患者呈现正相关和负相关。具体地说，右额下回的眶下部被认为具有监测功能。这些结果加强了左脑在失语症语言处理中的重要性，并为大脑中左右语言区域的相对重要性提供了一个框架。
Recovery from aphasia, loss of language following a cerebrovascular incident (stroke), is a complex process involving both left and right hemispheric regions. In our study, we analyzed the relationships between semantic processing behavioral data, lesion size and location, and functional percent signal change from functional magnetic resonance imaging (fMRI) data. This study included 14 persons with aphasia in the chronic stage of recovery (six or more months post stroke) and eight healthy controls who performed semantic processing tasks of determining whether a written semantic feature matched a picture or whether two written words were related or not. Using region of interest (ROI) analysis, we found that percent signal change in left inferior frontal gyrus pars opercularis and pars triangularis, despite significant damage, were the only regions to correlate with behavioral accuracy. Additionally, the more the damage to LIFG, LMTG and AG/SMG, the higher the percent signal change in bilateral superior frontal gyrus, middle frontal gyrus, and anterior cingulate, suggesting that these regions appear to serve as an assistive network in the case of damage to traditional language regions. Relative to controls who showed mainly positive correlations in activation between and within LH and RH ROIs, patients showed positive and negative correlations. Specifically, the right inferior frontal gyrus pars orbitalis is presumed to serve a monitoring function. These results reinforce the importance of the left hemisphere in language processing in aphasia, and provide a framework for the relative importance of left and right language regions in the brain.