A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis.
A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis.
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DOI：
10.1186/1742-4933-3-5
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发表时间：
2006-05-19
期刊：
影响因子：
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通讯作者：
Gollapudi S
中科院分区：
文献类型：
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作者：
Gupta S;Agrawal A;Agrawal S;Su H;Gollapudi S
衰老与免疫缺陷和炎症的矛盾有关（免疫系统过度活跃的证据）。细胞凋亡与细胞耗竭和炎症反应的抑制有关。在这篇简短的综述中，我们将提供证据证明细胞凋亡增加在免疫缺陷和与人类衰老相关的矛盾性炎症增加中的作用。特别是，凋亡细胞在未能产生抗炎反应和直接激活炎症反应中的作用将被讨论。
Aging is associated with a paradox of immunodeficiency and inflammation (an evidence of hyperactive immune system). Apoptosis is associated with cellular depletion and suppression of inflammatory response. In this brief review, we will present evidence for the role of increased apoptosis in immunodeficiency and paradoxical increased inflammation associated with human aging. In particular, a role of apoptotic cells in failure to generate anti-inflammatory responses and directly activating inflammatory responses will be discussed.