Initiation and promotion at different ages and doses in 2200 mice. II. Decrease in promotion by TPA with ageing.
Initiation and promotion at different ages and doses in 2200 mice. II. Decrease in promotion by TPA with ageing.
复制标题
在 2200 只小鼠中以不同年龄和剂量启动和促进。
作者：
F. Stenbäck;R. Peto;P. Shubik
使用论文I中描述的数据，我们比较了不同年龄段相同治疗时间和剂量的效果。在68周龄时开始使用DMBA，3周后使用TPA，对随后的肿瘤发病率的影响显著（P <0.0001）低于在8周龄或48周龄时开始使用，3周后使用TPA。我们认为，这主要是由于没有DMBA启动的细胞数量的变化，而是由于TPA在衰老小鼠中的促进功效降低。
Using the data described in Paper I, we compare the effects of the same treatment timings and doses given at different ages. Initiation with DMBA at 68 weeks of age, followed 3 weeks later by TPA, has a significantly (P less than 0.0001) less rapid effect on subsequent tumour incidence than does initiation at 8 or at 48 weeks of age, followed 3 weeks later by TPA. We suggested that this is chiefly due not to changes in the numbers of cells initiated by DMBA, but rather to a decrease in the promotional efficacy of TPA in ageing mice.