EVALUATION OF MARBLE-BURYING BEHAVIOR AS A MODEL OF ANXIETY
EVALUATION OF MARBLE-BURYING BEHAVIOR AS A MODEL OF ANXIETY
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DOI：
10.1016/0091-3057(91)90590-x
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发表时间：
1991-01-01
影响因子：
3.6
通讯作者：
HANDLEY, SL
中科院分区：
文献类型：
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作者：
NJUNGE, K;HANDLEY, SL
在单独放置在一个装有20个均匀分布的玻璃球的笼子里时，雌性MF1小鼠掩埋了7.8+/-0.2个弹珠。实验小鼠的手和性别的嗅觉刺激对埋藏数量没有影响，但当它们均匀分布时，大多数弹珠都被埋藏了。在连续测试或用弹珠预先安置这些新奇物体时，没有人会习惯性地使用弹珠，在两个隔间的盒子里，老鼠不会避开弹珠，它们一半的时间都呆在大理石一边。在药理实验中，分别测量了运动活性，以表明非特异性作用的可能性。抗焦虑药物育亨宾和β-β-卡洛林-3-羧酸乙酯(β-CCE)不能增加掩埋，育亨宾在剂量上减少了掩埋，也降低了运动活动。安定的作用与剂量有关：0.1 mg/kg增加埋藏量，0.25 mg/kg不增加埋藏量，1.0-5.0 mg/kg减少埋藏量。安定在0.1~2.5 mg/kg范围内可增加小鼠的运动能力，而在5.0 mg/kg范围内则无明显作用。齐美尔丁10.0 mg/kg可减少掩埋，但不能减少运动活动。抑制大理石埋藏可能是检测焦虑症的一个相关模型，而不是焦虑的同构模型。
On individual placement in a cage with 20 evenly spaced glass marbles, female MF1 mice buried 7.8 +/- 0.2 marbles. Olfactory stimuli from experiments hands and sex of mice had no influence on number buried, but most marbles were buried when they were evenly spaced. There was no habituation to these novel objects on serial testing or prehousing with marbles and, in a two-compartment box, mice did not avoid marbles, spending half their time on the marble side. In the pharmacological experiments, locomotor activity was measured separately to indicate the possibility of nonspecific effects. The anxiogenic agents yohimbine and ethyl-beta-carboline-3-carboxylate (beta-CCE) did not enhance burying, yohimbine decreased burying at doses also reducing locomotor activity. Diazepam effects depended on dose: 0.1 mg/kg increased burying, 0.25 mg/kg had no effect and 1.0-5.0 mg/kg reduced it. Diazepam increased locomotor activity from 0.1-2.5 mg/kg and had no effect at 5.0 mg/kg. Zimeldine, 10.0 mg/kg, reduced burying but not locomotor activity. Inhibition of marble burying may be a correlational model for detection of anxiolytics rather than an isomorphic model of anxiety.