Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12
Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12
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DOI：
10.2337/diabetes.45.11.1503
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发表时间：
1996-11-01
期刊：
影响因子：
7.7
通讯作者：
Polonsky, KS
中科院分区：
文献类型：
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作者：
Byrne, MM;Sturis, J;Polonsky, KS
一种形式的年轻人成熟型糖尿病（MODY）是由位于12号染色体q24带中的命名为MODY 3的基因突变引起的。本研究旨在确定MODY3突变受试者中葡萄糖和胰岛素分泌率（ISR）之间的相互作用。在13名MODY3受试者中，6名空腹血糖和糖化血红蛋白正常的受试者和7名明显糖尿病受试者被研究，6名非糖尿病对照受试者也被研究。每例受试者接受两次分级静脉内葡萄糖输注，间隔42小时连续静脉内葡萄糖输注，旨在激发β细胞分泌更多胰岛素以响应葡萄糖。通过外周C肽水平的去卷积来推导ISR。与非糖尿病受试者或正常健康对照受试者相比，MODY3糖尿病受试者的基础葡萄糖水平较高，胰岛素水平较低。作为对分级葡萄糖输注的响应，在广泛的葡萄糖浓度范围内，糖尿病受试者的ISR显著降低。非糖尿病MODY3受试者的ISR与对照受试者的血糖水平无显著差异
One form of maturity-onset diabetes of the young (MODY) results from mutations in a gene, designated MODY3, located on chromosome 12 in band q24. The present study was undertaken to define the interactions between glucose and insulin secretion rate (ISR) in subjects with mutations in MODY3. Of the 13 MODY3 subjects, six subjects with normal fasting glucose and glycosylated hemoglobin and seven overtly diabetic subjects were studied as were six nondiabetic control subjects. Each subject received graded intravenous glucose infusions on two occasions separated by a 42-h continuous intravenous glucose infusion designed to prime the beta-cell to secrete more insulin in response to glucose. ISRs were derived by deconvolution of peripheral C-peptide levels. Basal glucose levels were higher and insulin levels were lower in MODY3 subjects with diabetes compared with nondiabetic subjects or with normal healthy control subjects. In response to the graded glucose infusion, ISRs were significantly lower in the diabetic subjects over a broad range of glucose concentrations. ISRs in the nondiabetic MODY3 subjects were not significantly different from those of the control subjects at plasma glucose levels