Cell biology of valvular interstitial cells.
Cell biology of valvular interstitial cells.
复制标题
瓣膜间质细胞的细胞生物学。
DOI：
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发表时间：
1996
影响因子：
6.2
通讯作者：
A. Gotlieb
中科院分区：
文献类型：
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作者：
D. Mulholland;A. Gotlieb
客观化
综述心脏瓣膜间质细胞的细胞生物学。在研究心脏瓣膜间质细胞功能时，作者观察到猪二尖瓣间质细胞具有混合表型表达。
数据源
1985年至1995年的英文文献，讨论心脏瓣膜间质细胞的细胞生物学，包括它们的结构和功能特征。
结果
从形态上看，心脏瓣膜间质细胞既具有成纤维细胞的特性，又具有平滑肌细胞的特性。然而，目前尚不清楚这些细胞是否代表一种(肌成纤维细胞)细胞类型，或者瓣膜内是否有两组细胞。本文综述了心脏瓣膜间质细胞的结构和功能特点，包括超微结构、细胞连接、平滑肌细胞标志物、细胞生长、在伤口修复和收缩中的作用。
结论
血管间质细胞在正常瓣膜和病变瓣膜中都发挥着重要作用。我们对瓣膜间质细胞的异质性的理解是不完整的；然而，这种异质性允许执行多种功能，包括细胞间通讯、基质分泌、伤口修复和收缩。未来的研究需要将重点放在细胞异质性的调节上，因为它与健康和疾病中的瓣膜结构和功能有关。
OBJECTIVE
To review the cell biology of the interstitial cells of heart valves. While studying the function of interstitial cells of heart valves, the authors observed that interstitial cells from porcine mitral valve have mixed phenotypic expression.
DATA SOURCE
English-language literature from 1985-95 that discussed the cell biology of heart valve interstitial cells, including their structural and functional characteristics.
RESULTS
Morphologically, heart valve interstitial cells have characteristics of both fibroblasts and smooth muscle cells. It is not clear, however, whether these cells represent a single (myofibroblast) cell type or whether there are two populations of cells within the valve. This review summarizes reports of the structural and functional characteristics of heart valve interstitial cells including ultrastructure, cell junctions, smooth muscle cell markers, cell growth, role in wound repair and contractility.
CONCLUSIONS
Vascular interstitial cells play an important role in both normal and diseased valves. Our understanding of the heterogeneity of valvular interstitial cells is incomplete; however, this heterogeneity allows for multiple functions to be carried out including cell-cell communication, matrix secretion, wound repair and contractility. Future studies are needed to focus on the regulation of cellular heterogeneity as it relates to valve structure and function in health and disease.