Biological effects of intermittent radiation in cultured tumor cells: Influence of fraction number and dose per fraction
Biological effects of intermittent radiation in cultured tumor cells: Influence of fraction number and dose per fraction
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DOI：
10.1269/jrr.46.401
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发表时间：
2005-12-01
影响因子：
2
通讯作者：
Ito, M
中科院分区：
文献类型：
--
作者：
Ogino, H;Shibamoto, Y;Ito, M
在使用线性加速器的调强放射治疗（IMRT）和立体定向照射中，间歇地施用放射，并且一个疗程通常需要30分钟或更长的时间。本研究的目的是调查的影响，分次和剂量每部分的细胞杀伤辐射在间歇曝光。使用鼠EMT 6和SCCVII细胞。在15、30和46 min内分2、5、10、20和40次照射细胞，总剂量为8戈伊。在15、30和46 min内使用较低剂量率（连续延长照射组）单次给予细胞8戈伊。与以1.55戈伊/min的剂量接受8戈伊单次照射的对照组相比，接受分次或连续延长照射的组的细胞存活分数普遍增加。在两种细胞系中，细胞存活率随级分数增加至20或40级分而增加的总体趋势。IMRT和直线加速器放射外科治疗超过15分钟或更长时间的效果可能小于1或2分次照射。随着馏分数的增加，辐照效应有降低的趋势。
In intensity-modulated radiation therapy (IMRT) and stereotactic irradiation using a linear accelerator, radiation is administered intermittently and one treatment session often requires 30 min or a longer time. The purpose of the present study was to investigate the effect of fractionation and dose per fraction on cell killing by irradiation in intermittent exposure. Murine EMT6 and SCCVII cells were used. The cells were irradiated to a total dose of 8 Gy in 2, 5, 10, 20 and 40 fractions over 15, 30 and 46 min. The cells were also given 8 Gy in a single fraction over 15, 30 and 46 min using lower dose rates (continuous prolonged radiation groups). As compared with the control group receiving a single dose of 8 Gy at 1.55 Gy/min, the cell surviving fraction generally increased in groups receiving fractionated or continuous prolonged radiation. There was a general trend for cell survival to increase with the fraction number up to 20 or 40 fractions in both cell lines. The effects of IMRT and linear accelerator radiosurgery given over 15 min or longer may be less than those of 1- or 2-fraction irradiation. There was a trend for radiation effect to decrease with fraction number.