Phagocytosis and intracellular killing of pathogenic yeasts by human monocytes and neutrophils
Phagocytosis and intracellular killing of pathogenic yeasts by human monocytes and neutrophils
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人单核细胞和中性粒细胞对致病酵母的吞噬作用和胞内杀伤作用
DOI：
10.1128/iai.24.3.932-938.1979
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发表时间：
1979
影响因子：
3.1
通讯作者：
K. E. Schuit
中科院分区：
文献类型：
--
作者：
K. E. Schuit
检查了两种类型的吞噬细胞对具有不同毒力的四种真菌形式的吞噬和杀死的动力学。人类单核细胞摄取酿酒酵母、热带假丝酵母和白色念珠菌芽生孢子的速度比人类中性粒细胞更快。这两种细胞类型对白色念珠菌假菌丝的吞噬率没有差异。单核细胞对四种真菌形式中每一种的细胞内杀伤速度始终明显快于中性粒细胞。中性粒细胞无法破坏摄入的白色念珠菌假菌丝。这些实验表明，单核细胞在宿主防御真菌疾病方面发挥着重要作用，并且人类疾病中致病酵母的相对毒力可能与这些生物体被循环吞噬细胞摄入后的生存能力有关。
The kinetics of phagocytosis and killing of four fungal forms with varying virulence by two types of phagocytic cells was examined. Human monocytes ingested Saccharomyces cerevisiae, Candida tropicalis, and the blastospores of Candida albicans more rapidly than did human neutrophils. There was no difference in the rate of phagocytosis of C. albicans pseudohyphae by these two cell types. Intracellular killing of each of the four fungal forms was consistently and significantly more rapid by monocytes than by neutrophils. Neutrophils were unable to destroy ingested C. albicans pseudohyphae. These experiments suggest that the monocyte plays an important role in host defenses against fungal diseases and that the relative virulence of the pathogenic yeasts in human disease may be related to the ability of these organisms to survival after being ingested by circulating phagocytes.