Long-Term Impact of Arsenic in Drinking Water on Bladder Cancer Health Care and Mortality Rates 20 Years After End of Exposure
Long-Term Impact of Arsenic in Drinking Water on Bladder Cancer Health Care and Mortality Rates 20 Years After End of Exposure
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DOI：
10.1016/j.juro.2011.10.157
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发表时间：
2012-03-01
影响因子：
6.6
通讯作者：
Coz, Fernando
中科院分区：
文献类型：
--
作者：
Fernandez, Mario I.;Francisco Lopez, J.;Coz, Fernando
目的：在这项研究中，我们评估了近几十年来在北方智利砷暴露区的膀胱癌保健和死亡率趋势。材料和方法：在受影响的地区获得了过去60年的砷水平，并与近几十年来膀胱癌的出院率和死亡率相关。受影响地区的膀胱癌出院率显著较高（峰值RR 3.6，95% CI 3.0-4.7）。膀胱癌的死亡率在分析期间呈上升趋势，在过去10年中达到男性每100 000人死亡28.4人和女性每100 000人死亡18.7人的高峰。泊松回归模型显示，与该国其他地区相比，研究地区男性（IRR 5.3，95% CI 4.8-5.8）和女性（IRR 7.8，95% CI 7.0-8.7）的死亡风险增加。暴露地区癌症特异性死亡的平均年龄显著较低（69.6岁，95% CI 68.4-70.7 vs 73.7岁，95% CI 73.3-74.2，p
Purpose: In this study we assessed bladder cancer health care and mortality trends in recent decades in a well studied arsenic exposed area in Northern Chile.Materials and Methods: Arsenic levels in the affected region were obtained for the last 60 years, and correlated with bladder cancer hospital discharge and mortality rates in recent decades.Results: Bladder cancer hospital discharge rates were significantly higher in the affected region (peak RR 3.6, 95% CI 3.0-4.7). Mortality rates for bladder cancer showed a trend of increase during the period analyzed, reaching peak mortality rates of 28.4 per 100,000 for men and 18.7 per 100,000 for women in the last 10 years. Poisson regression models showed an increased mortality risk in the studied region compared to the rest of the country until the present for men (IRR 5.3, 95% CI 4.8-5.8) and women (IRR 7.8, 95% CI 7.0-8.7). Mean age at cancer specific death was significantly lower in the exposed region (69.6 years, 95% CI 68.4-70.7 vs 73.7 years, 95% CI 73.3-74.2, p