Constrained and UV-activatable cell-penetrating peptides for intracellular delivery of liposomes
Constrained and UV-activatable cell-penetrating peptides for intracellular delivery of liposomes
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DOI：
10.1016/j.jconrel.2012.10.008
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发表时间：
2012-11-28
影响因子：
10.8
通讯作者：
Lowik, Dennis W. P. M.
中科院分区：
文献类型：
--
作者：
Hansen, Morten B.;van Gaal, Ethlinn;Lowik, Dennis W. P. M.
Herein we report on the development of a novel method of constraining a cell-penetrating peptide, which can be used to trigger transport of liposomes into cells upon in this case radiation with UV-light. A cell-penetrating peptide, which was modified on both termini with an alkyl chain, was anchored to the liposomal surface in a constrained and deactivated form. Since one of the two alkyl chains was connected to the peptide via a UV-cleavable linker, disconnection of this alkyl chain upon irradiation led to the exposure of the cell-penetrating peptide, and mediated the transport of the entire liposome particle into cells. (C) 2012 Elsevier B.V. All rights reserved.
