Comparative assessment of HPHC yields in the Tobacco Heating System THS2.2 and commercial cigarettes
Comparative assessment of HPHC yields in the Tobacco Heating System THS2.2 and commercial cigarettes
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DOI：
10.1016/j.yrtph.2017.08.006
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发表时间：
2017-11-01
影响因子：
3.4
通讯作者：
Belushkin, M.
中科院分区：
文献类型：
--
作者：
Jaccard, G.;Djoko, D. Tafin;Belushkin, M.
近年来，人们一直在努力开发与继续吸烟相比风险更低的产品，作为成年吸烟者的替代品，否则他们将继续吸烟。在这些产品的非临床评估阶段，其气溶胶的化学成分和毒性经常与标准研究香烟-3R 4F参考香烟的烟雾的化学成分和毒性进行比较。在本研究中，它表明，这些分析比较的结果是相似的，当考虑全球范围内的市售卷烟产品。在候选改良风险烟草产品（烟草加热系统2.2）的气溶胶中测量的各种有害和潜在有害成分（HPHC）中，平均观察到约90%的市场平均减少（THS 2.2），与选定市场代表性香烟的HPHC水平进行比较;该平均降低与先前研究中针对3R 4F烟雾成分观察到的降低完全一致。(C)2017作者爱思唯尔公司出版
There has been a sustained effort in recent years to develop products with the potential to present less risk compared with continued smoking as an alternative for adult smokers who would otherwise continue to smoke cigarettes. During the non-clinical assessment phase of such products, the chemical composition and toxicity of their aerosols are frequently compared to the chemical composition and toxicity of the smoke from a standard research cigarette - the 3R4F reference cigarette. In the present study, it is demonstrated that results of these analytical comparisons are similar when considering commercially available cigarette products worldwide. A market mean reduction of about 90% is observed on average across a broad range of harmful and potentially harmful constituents (HPHC) measured in the aerosol of a candidate modified risk tobacco product, the Tobacco Heating System 2.2 (THS2.2), compared against the levels of HPHC of cigarettes representative of selected markets; this mean reduction is well in line with the reduction observed against 3R4F smoke constituents in previous studies. (C) 2017 The Authors. Published by Elsevier Inc.