Diffusion tensor imaging of the corpus callosum in Autism
Diffusion tensor imaging of the corpus callosum in Autism
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DOI：
10.1016/j.neuroimage.2006.08.032
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发表时间：
2007-01-01
期刊：
影响因子：
5.7
通讯作者：
Lainhart, Janet E.
中科院分区：
文献类型：
--
作者：
Alexander, Andrew L.;Lee, Jee Eun;Lainhart, Janet E.
胼胝体是连接人类大脑半球的最大的连合性白质通路。在这项研究中，对高功能自闭症患者组以及年龄、利手、智商和头围相匹配的对照组进行了扩散张量成像（DTI）。对整个胼胝体及其亚区（膝部、体部和压部）进行了DTI和体积测量，并在组间进行了比较。结果显示，组间在体积、分数各向异性、平均扩散率和径向扩散率方面存在显著差异。这些组间差异似乎是由自闭症组的一个亚组驱动的，该亚组胼胝体体积小、平均扩散率高、各向异性低且径向扩散率增加。这个亚组的操作智商测量值明显低于其他自闭症个体或对照组。径向扩散率的测量值似乎也与操作智商测试期间测量的处理速度相关。平均扩散率高且分数各向异性低的自闭症亚组似乎与最高的径向扩散率和最慢的处理速度聚集在一起。这些结果表明，自闭症患者的胼胝体微观结构受到影响，这可能与非言语认知表现有关。（c）2006爱思唯尔公司。保留所有权利。
The corpus callosum is the largest commissural white matter pathway that connects the hemispheres of the human brain. In this study, diffusion tensor imaging (DTI) was performed on subject groups with high-functioning autism and controls matched for age, handedness, IQ, and head size. DTI and volumetric measurements of the total corpus callosum and subregions (genu, body and splenium) were made and compared between groups. The results showed that there were significant differences in volume, fractional anisotropy, mean diffusivity, and radial diffusivity between groups. These group differences appeared to be driven by a subgroup of the autism group that had small corpus callosum volumes, high mean diffusivity, low anisotropy, and increased radial diffusivity. This subgroup had significantly lower performance IQ measures than either the other individuals with autism or the control subjects. Measurements of radial diffusivity also appeared to be correlated with processing speed measured during the performance IQ tests. The subgroup of autism subjects with high mean diffusivity and low fractional anisotropy appeared to cluster with the highest radial diffusivities and slowest processing speeds. These results suggest that the microstructure of the corpus callosum is affected in autism, which may be related to nonverbal cognitive performance. (c) 2006 Elsevier Inc. All rights reserved.