Conservation of sequence and function in the Pax6 regulatory elements
Conservation of sequence and function in the Pax6 regulatory elements
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DOI：
10.1016/j.tig.2004.04.009
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发表时间：
2004-07-01
影响因子：
11.4
通讯作者：
Morgan, R
中科院分区：
文献类型：
--
作者：
Morgan, R
Pax6转录因子是眼睛和大脑发育的高度保守的调节因子。其复杂的调控模式在果蝇和脊椎动物之间是相同的，尽管它们的增强子和启动子区域之间没有显著的序列同源性。在这篇文章中，对Pax6基因组序列的更详细的研究揭示了一组共同的推测的Pax6和基本螺旋-环-螺旋转录因子结合位点。
The Pax6 transcription factor is a highly conserved regulator of eye and brain development. Its complex mode of regulation is shared between Drosophila melanogaster and the vertebrates, despite there being no significant sequence identity between their enhancer and promoter regions. In this article, a more detailed examination of the Pax6 genomic sequence reveals a common set of putative Pax6 and basic helix-loop-helix transcription factor binding sites.