Reduced high and low frequency gamma synchronization in patients with chronic schizophrenia
Reduced high and low frequency gamma synchronization in patients with chronic schizophrenia
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DOI：
10.1016/j.schres.2011.07.020
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发表时间：
2011-12
影响因子：
4.5
通讯作者：
R. Tsuchimoto;S. Kanba;S. Hirano;N. Oribe;T. Ueno;Y. Hirano;I. Nakamura;Y. Oda;T. Miura;T. Onitsuka
中科院分区：
文献类型：
--
作者：
R. Tsuchimoto;S. Kanba;S. Hirano;N. Oribe;T. Ueno;Y. Hirano;I. Nakamura;Y. Oda;T. Miura;T. Onitsuka
精神分裂症的概念是与神经回路异常相关的功能失调的认知和行为。神经回路的功能可以使用听觉稳态反应（ASSR）来评估。此外，近年来，对高（>60Hz）伽马带振荡的研究越来越引起人们的兴趣。当前的研究使用全头 306 通道脑磁图 (MEG)，并通过 ASSR 研究低和高伽马带振荡。受试者包括 17 名精神分裂症患者和 22 名对照者。目前的研究调查了 20、30、40 和 80 Hz 频率的点击序列引发的 MEG-ASSR，以及精神分裂症患者的症状与 ASSR 的关联。估计了 ASSR 的平均功率、锁相因子、偶极矩和源位置。主要发现是：（1）精神分裂症患者在 40 Hz 和 80 Hz 频率下表现出双侧 ASSR 功率和偶极矩降低； (2)与健康受试者相比，精神分裂症患者的40Hz ASSR右大于左功率和锁相因子较低，这表明精神分裂症患者可能以40Hz ASSR异常不对称为特征； (3) 精神分裂症患者整体幻觉体验严重程度的增加与较小的左侧 80 Hz MEG-ASSR 显着相关。目前的研究强调了高频和低频伽玛异常，并提供了明确的证据表明精神分裂症的特征是神经回路异常。
Schizophrenia has been conceptualized by dysfunctional cognition and behavior related to abnormalities in neural circuitry. The functioning of the neural circuitry can be assessed using the auditory steady state response (ASSR). Moreover, in recent years, research on high (>60Hz) gamma band oscillations has become of increasing interest. The current study used whole-head, 306-channel magnetoencephalography (MEG) and investigated low and high gamma band oscillations with the ASSR. The subjects comprised 17 patients with schizophrenia and 22 controls. The current study investigated the MEG-ASSR elicited by click trains of 20-, 30-, 40- and 80-Hz frequencies, and symptom–ASSR associations in patients with schizophrenia. The mean power, phase-locking factor, dipole moments and source locations of the ASSR were estimated. The main findings were: (1) patients with schizophrenia showed bilaterally reduced ASSR power and dipole moments specific to the 40-Hz and 80-Hz frequencies; (2) patients with schizophrenia showed less right-greater-than-left 40-Hz ASSR power and phase-locking factor compared with healthy subjects, indicating that schizophrenics may be characterized by an abnormal asymmetry of the 40-Hz ASSR; (3) increased severity of global hallucinatory experiences was significantly associated with smaller left 80-Hz MEG–ASSR in patients with schizophrenia. The current study highlights the high and low frequency gamma abnormalities and provides clear evidence that schizophrenia is characterized by abnormalities in neural circuitry.