The role of alpha adrenoceptors in the vascular and estradiol secretory responses to stimulation of the superior ovarian nerve
The role of alpha adrenoceptors in the vascular and estradiol secretory responses to stimulation of the superior ovarian nerve
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DOI：
10.1007/s12576-011-0135-1
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发表时间：
2011-05-01
影响因子：
2.3
通讯作者：
Hotta, Harumi
中科院分区：
文献类型：
--
作者：
Kagitani, Fusako;Uchida, Sae;Hotta, Harumi
电刺激大鼠卵巢上级神经可降低卵巢静脉血的血浆流速（卵巢血流量）和卵巢雌二醇分泌速率。在这里，我们研究了α肾上腺素受体在这些过程中可能发挥的作用。血浆流速的降低被α 1-（哌唑嗪）阻断，但不能被α 2-（育亨宾）肾上腺素受体阻滞剂阻断。与此相反，雌二醇分泌率的降低被育亨宾阻断，而不是哌唑嗪。我们的结论是卵巢血管和雌二醇分泌反应的上级卵巢神经激活介导的α 1和α 2肾上腺素受体，分别。
Electrical stimulation of the superior ovarian nerve in rats reduces both the plasma flow rate of ovarian venous blood (ovarian blood flow) and the ovarian estradiol secretion rate. Here, we examined the possible roles of alpha-adrenoceptors in these processes. The reduction of the plasma flow rate was blocked by an alpha 1-(prazosin), but not by an alpha 2-(yohimbine) adrenoceptor blocker. In contrast, the reduction of the estradiol secretion rate was blocked by yohimbine but not by prazosin. We conclude that ovarian vascular and estradiol secretory responses to superior ovarian nerve activation are mediated by alpha 1- and alpha 2-adrenoceptors, respectively.