Comparison of vaccine strategies against congenital CMV infection in the guinea pig model
Comparison of vaccine strategies against congenital CMV infection in the guinea pig model
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DOI：
10.1016/j.jcv.2007.10.008
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发表时间：
2008-03-01
影响因子：
8.8
通讯作者：
Schleiss, Mark R.
中科院分区：
文献类型：
--
作者：
Schleiss, Mark R.
迫切需要疫苗来保护新生儿免受先天性巨细胞病毒感染的毁灭性后遗症。在先天性感染豚鼠模型中评价候选疫苗可以阐明对人类潜在有用的策略，因为豚鼠CMV（GPCMV）经胎盘传播给胎儿，引起子宫内的感染和疾病。许多疫苗策略已在该模型中进行了评估，包括DNA疫苗、减毒活疫苗和重组糖蛋白疫苗。病毒中和抗体的诱导似乎在保护胎儿中起关键作用。最近，基于UL83（pp65）蛋白的GPCMV同源物的载体疫苗也已被证明是有效的，当在该模型中用作前概念疫苗时，这表明设计用于引发T细胞应答的策略可能在保护胎儿方面具有价值。(C)2007 Elsevier B.V.保留所有权利。
Vaccines are urgently needed to protect newborns against the devastating sequelae of congenital cytomegalovirus infection. Evaluation of candidate vaccines in the guinea pig model of congenital infection can shed light on potentially useful strategies for humans, Since guinea pig CMV (GPCMV) is transmitted to the fetus transplacentally, causing infection and disease in utero. A number of vaccine strategies have been evaluated in this model, including DNA vaccines, live attenuated vaccines, and recombinant glycoprotein vaccines. Induction of virus-neutralizing antibody appears to play a key role in protection of the fetus. Recently, a vectored vaccine based on the GPCMV homolog of the UL83 (pp65) protein has also been shown to be effective when used as a preconceptual vaccine in this model, suggesting that strategies designed to elicit T-cell responses may be of value in protection of the fetus. (C) 2007 Elsevier B.V. All rights reserved.