HORMONAL DEPENDENCE OF PINOPODE FORMATION AT THE UTERINE LUMINAL SURFACE
HORMONAL DEPENDENCE OF PINOPODE FORMATION AT THE UTERINE LUMINAL SURFACE
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DOI：
10.1093/oxfordjournals.humrep.a137386
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发表时间：
1991-04-01
影响因子：
6.1
通讯作者：
PSYCHOYOS, A
中科院分区：
文献类型：
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作者：
MARTEL, D;MONIER, MN;PSYCHOYOS, A
子宫腔上皮在接受着床期显示其顶面的特征性突起，称为胞饮突。 雌二醇和孕酮，单独或组合，对胞饮突的形成和消退的影响进行了研究，使用扫描电子显微镜。 胞饮突的出现被认为是严格依赖于孕酮。 当与孕酮一起给药时，在胞饮突发育之前，高剂量的雌二醇（血浆水平约为300 pmol/l）抑制胞饮突的形成;相反，低剂量的雌二醇（nidatory剂量）直到治疗的第4天才干扰该过程。 当雌二醇作为单次注射时，在胞饮突形成后，两种剂量在48-72小时后诱导其消退方面是等效的。 看来胞饮突形成的激素调节和卵子植入的子宫容受性的发育是相同的。 这些观察结果支持这一假设，即胞饮突可能是一个非常有用的工具，以估计子宫容受性。 我们在这里描述的实验，以及几年前在人类刺激周期中所做的观察，表明在排卵和着床之间的时间内由于激素失衡而导致的着床失败可能是一种普遍现象。
The uterine luminal epithelium during the period of receptivity for nidation displays characteristic protrusions of the apical surface named pinopodes. The effects of oestradiol and progesterone, singly or in combination, on the formation and regression of pinopodes were investigated using scanning electron microscopy. The appearance of pinopodes was found to be strictly progesterone dependent. When given together with progesterone, before the development of pinopodes, high doses of oestradiol (plasma level approximately 300 pmol/l) inhibited pinopode formation; on the contrary, low doses of oestradiol (nidatory doses) did not interfere with the process until the 4th day of treatment. When oestradiol was given as a single injection, after pinopode formation, both doses were equivalent in inducing their regression 48-72 h later. It appears that the hormonal conditioning for pinopode formation and for the development of uterine receptivity for egg implantation is the same. These observations support the hypothesis that pinopodes could be an extremely useful tool to estimate uterine receptivity. The experiments we describe here, together with observations made a few years ago, in stimulated cycles in the human, suggest that implantation failure as a result of a hormonal imbalance during the time intervening between ovulation and nidation, may be a general phenomenon.