Dietary habits and risk of death due to hepatocellular carcinoma in a large scale cohort study in Japan. Univariate analysis of JACC Study data
Dietary habits and risk of death due to hepatocellular carcinoma in a large scale cohort study in Japan. Univariate analysis of JACC Study data
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DOI：
10.2739/kurumemedj.51.141
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发表时间：
2004-01-01
影响因子：
--
通讯作者：
Tamakoshi, Akiko
中科院分区：
文献类型：
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作者：
Kurozawa, Youichi;Ogimoto, Itsuro;Tamakoshi, Akiko
为了探讨日本饮食习惯与肝细胞癌（HCC）死亡风险之间的关系，使用JACC研究的数据进行了单变量分析。1988-1990年期间，日本19个县年龄在40至79岁之间的46,465名男性和64,327名女性完成了基线调查，并一直随访到1999年底。采用Cox比例风险模型，按性别、年龄组别（40-59岁和60-79岁）和肝病史划分各食品HCC死亡率的风险比（HR）。无肝脏病史的男性食用水煮米饭、火腿和香肠、鸡肉、鱼和泡菜，无肝脏病史的女性食用味噌汤、鱼、胡萝卜和南瓜、土豆等食物与HCC死亡率呈显著负相关。在没有肝脏疾病史的男性中，频繁摄入鸡蛋与HCC死亡率增加显著相关。在有肝脏疾病史的男性中，土豆和用酱油煮熟的食物（tsukudani）与HCC死亡率呈显著正相关，泡菜与HCC死亡率呈显著负相关。在有肝脏疾病史的男性和女性中，经常摄入咖啡与HCC死亡率呈显著负相关。考虑到需要使用包含其他混杂因素的多变量Cox比例风险模型进行进一步分析，以便对数据进行更有意义的解释。
To explore the association between dietary habits and risk of hepatocellular carcinoma (HCC) mortality in Japan, univariate analyses was performed using data from the JACC Study. A cohort of 46,465 males and 64,327 females aged 40 to 79 in 19 prefectures in Japan completed the baseline survey during 1988-1990 and were followed up until the end of 1999. The hazard ratio (HR) of HCC mortality for each food item by gender, age group (40-59 and 60-79 years) and history of liver diseases was obtained by Cox proportional hazards model. Some categories, such as boiled rice, ham and sausage, chicken, fish and pickles among men without history of liver diseases and those of miso-soup, fish, carrots and squash, and potatoes among women without history of liver diseases showed a significant inverse association with HCC mortality. Frequent intake of eggs was significantly associated with increased HCC mortality in men without history of liver diseases. Potatoes and foods boiled down in soy sauce (tsukudani) showed a significant positive association, and pickles had a significant inverse association with HCC mortality in men with history of liver diseases. Frequent intake of coffee showed a significant inverse association with HCC mortality both in men and women with history of liver diseases. It is considered that further analysis using a multivariate Cox proportional hazards model including other confounding factors will be required for a more meaningful interpretation of the data.