Iron Catalyzed Dual-Oxidative Dehydrogenative (DOD) Tandem Annulation of Glycine Derivatives with Tetrahydrofurans
Iron Catalyzed Dual-Oxidative Dehydrogenative (DOD) Tandem Annulation of Glycine Derivatives with Tetrahydrofurans
复制标题
铁催化甘氨酸衍生物与四氢呋喃的双氧化脱氢 (DOD) 串联环化
DOI：
10.1021/acs.orglett.5b02504
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发表时间：
2015
期刊：
影响因子：
5.2
通讯作者：
Wang Yajun
中科院分区：
文献类型：
--
作者：
Huo Congde;Chen Fengjuan;Yuan Yong;Xie Haisheng;Wang Yajun
研究了一种新型的铁催化甘氨酸衍生物与四氢呋喃的双氧化还原（DOD）串联成环反应，用于合成高价值的喹啉稠合内酯。反应在温和的反应条件下进行。并且使用廉价的底物（甘氨酸衍生物和THF）和甚至更便宜的简单无机铁盐作为催化剂使得该方案对于潜在的合成应用非常有吸引力。
A novel iron-catalyzed dual-oxidative dehydrogenative (DOD) tandem annulation of glycine derivatives with tetrahydrofurans (THFs) for the synthesis of high value quinoline fused lactones has been developed. The reactions were performed under mild reaction conditions. And the use of cheap substrates (glycine derivatives and THF) and an even cheaper simple inorganic iron salt as the catalyst makes this protocol very attractive for potential synthetic applications.