Neural correlates of naming errors across different neurodegenerative diseases An FDG-PET study
Neural correlates of naming errors across different neurodegenerative diseases An FDG-PET study
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DOI：
10.1212/wnl.0000000000010967
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发表时间：
2020-11-17
期刊：
影响因子：
9.9
通讯作者：
Perani, Daniela
中科院分区：
文献类型：
--
作者：
Catricala, Eleonora;Polito, Cristina;Perani, Daniela
目的
研究不同病因所致神经退行性痴呆患者在图片命名任务中产生的错误类型及其神经相关性。
方法
对连续的一组已进行[F - 18]氟脱氧葡萄糖正电子发射断层扫描（FDG - PET）研究的患者（n = 148）进行相同的标准化图片命名测试。将错误分为3类（视觉、语义和语音）进行分析。使用优化的单样本程序分析PET数据，并采用统计参数映射多元回归设计来探究整个组中每种错误类型与脑低代谢之间的相关性。在组水平上对与先验定义的命名网络相对应的7个左半球皮质区域进行代谢连接性分析。
结果
大多数患者以语义错误为主，与临床诊断无关。在全组分析中，视觉错误与右侧枕叶下回和左侧枕叶中回的低代谢相关。语义错误与左侧梭状回、颞叶下回和中回以及颞极的低代谢相关。语音错误与左侧颞叶上回和中回的低代谢有关。正性（枕叶 - 梭状回后部）和负性（梭状回前部和颞叶前上回）连接性变化均与语义错误相关。
结论
命名错误反映了命名过程中不同阶段的功能障碍，是不同脑受累模式的特异性标志物。这些相关性不仅限于原发性进行性失语症，还延伸到其他神经退行性痴呆。
ObjectiveTo investigate the types of errors produced in a picture naming task by patients with neuro-degenerative dementia due to different etiologies and their neural correlates.MethodsThe same standardized picture naming test was administered to a consecutive sample of patients (n = 148) who had been studied with [F-18] FDG-PET. The errors were analyzed in 3 categories (visual, semantic, and phonologic). The PET data were analyzed using an optimized single-subject procedure, and the statistical parametric mapping multiple regression design was used to explore the correlation between each type of error and brain hypometabolism in the whole group. Metabolic connectivity analyses were run at the group level on 7 left hemisphere cortical areas corresponding to an a priori defined naming network.ResultsSemantic errors were predominant in most patients, independent of clinical diagnosis. In the whole group analysis, visual errors correlated with hypometabolism in the right inferior occipital lobe and in the left middle occipital lobe. Semantic errors correlated with hypometabolism in the left fusiform gyrus, the inferior and middle temporal gyri, and the temporal pole. Phonologic errors were associated with hypometabolism in the left superior and middle temporal gyri. Both positive (occipital-posterior fusiform) and negative (anterior fusiform gyrus and the superior anterior temporal lobe) connectivity changes were associated with semantic errors.ConclusionsNaming errors reflect the dysfunction of separate stages of the naming process and are specific markers for different patterns of brain involvement. These correlations are not limited to primary progressive aphasia but extend to other neurodegenerative dementias.