Amygdala kindling in juvenile rats following neonatal administration of 6-hydroxydopamine.
Amygdala kindling in juvenile rats following neonatal administration of 6-hydroxydopamine.
复制标题
新生大鼠给予 6-羟基多巴胺后杏仁核点燃。
DOI：
10.1016/0014-4886(85)90156-6
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发表时间：
1985
影响因子：
5.3
通讯作者：
Buterbaugh,GG
中科院分区：
文献类型：
--
作者：
Michelson,HB;Buterbaugh,GG
The role of catecholamines in mediating the acquisition of amygdala-kindled seizures was investigated in juvenile rats administered intracisternal injections of 6-hydroxydopamine (6-OHDA) on postnatal days 1 and 2. Amygdala kindling was initiated on day 28, using stimulations delivered each hour through two consecutive stage V seizures. The 6-OHDA treatment resulted in a 53% increase in the overall rate of kindling in juvenile rats. This acceleration was confined primarily to the early phases of kindling in that the 6-OHDA-treated rats skipped the early kindling stages, and the later stages of kindling were unaffected. These findings support evidence from adult rats that catecholamines play a role in initially limiting the spread of seizure activity during kindled seizure acquisition; however, when the seizures have begun to generalize, the ability of catecholaminergic systems to inhibit seizure spread diminishes.
