Classification of human liver transplant recipients by their preoperative CD8+ T cell subpopulation and its relation to outcome
Classification of human liver transplant recipients by their preoperative CD8+ T cell subpopulation and its relation to outcome
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DOI：
10.1002/lt.20705
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发表时间：
2006-05-01
影响因子：
4.6
通讯作者：
Minato, Nagahiro
中科院分区：
文献类型：
--
作者：
Tanaka, Koichi;Ozawa, Kazue;Minato, Nagahiro
T细胞的启动状态在肝移植受者中是显著不同的，这是由于终生的抗原暴露以及衰老和疾病导致的胸腺生成减少。本研究旨在描述术前CD 8（+）T细胞亚群的免疫状态，并将其与肝移植受者的结局联系起来。我们将112例肝移植受者分为5组，根据T细胞的CD 8（+）CD 45亚型比例的分层聚类。在第I组和第11组（儿科）中，初始T细胞比例超过50%。在成年受者中，第III组的特征在于幼稚T细胞比例为50%，第IV组具有最大的效应/记忆T细胞（EM），并且第V组具有最大比例的效应T细胞。在第IV组和第V组中，效应T细胞比例相当高，并且伴随着CD 27（+）CD 28（+）亚群的显著下调和干扰素γ（IFN）-γ、肿瘤坏死因子-α和穿孔素表达的上调。V组受者术后并发症多，生存率显著降低（1年，66.8%），东部肿瘤协作组体能状态显著降低。
The primed status of T cells is markedly different among liver transplant recipients, due to a lifetime of antigen exposure and reduced thymopoiesis by aging, and diseases. This study aims to characterize the preoperative immunological status of CD8(+) T cell subpopulations and relate it to the outcome for liver transplant recipients. We classified 112 liver transplant recipients into 5 groups, based on hierarchical clustering of the CD8(+)CD45 isoform proportion of T cells. In Groups I and 11 (pediatric), the naive T cell proportion was more than 50%. In adult recipients, Group III was characterized by a naive T cell proportion of 50%, Group IV had the greatest effector/memory T cells (EM), and Group V had the greatest proportion of effector T cells. In Groups IV and V, the effector T cell proportion was considerably higher, and was accompanied by marked downregulation of the CD27(+)CD28(+) subsets and upregulation of interferon gamma (IFN)-gamma, tumor necrosis factor-alpha, and perforin expression. Group V recipients tended to be complicated postoperatively, with a significantly reduced survival rate (1 yr, 66.8%) and markedly reduced Eastern Cooperative Oncology Group performance status.