Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus
Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus
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DOI：
10.2220/biomedres.44.17
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发表时间：
2023-01-01
影响因子：
1.2
通讯作者：
Marunaka, Yoshinori
中科院分区：
文献类型：
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作者：
Hosogi, Shigekuni;Kuwahara, Atsukazu;Marunaka, Yoshinori
本研究试图阐明木瓜提取物是否能预防高血糖，这是2型糖尿病(T2 DM)的典型症状之一，因为木瓜提取物是从日本杏子中提取出来的，可以预防高血糖。为了阐明粘液是否能预防T2 DM的发病，我们采用了大冢Long-Evans Tokushima肥胖(OLETF)大鼠的T2 DM模型。吗替芬可降低OLETF大鼠禁食条件下的高血糖、HOMA-IR和血浆甘油三酯浓度。此外，远端结肠中钠偶联单羧酸转运体1(SMCT1)的蛋白表达增加，参与弱有机酸的吸收，弱有机酸在吸收到体内后表现为碱而不是酸。与非T2 DM LETO大鼠相比，OLETF大鼠脑海马区间质pH值明显降低。脑内淀粉样β蛋白的积累量随pH升高而减少。一方面，在禁食条件下，麦角不影响血浆中胰高血糖素、GLP-1、GIP或PYY的浓度。综上所述，这些观察表明：1)麦芽果是一种有用的功能食品，可以改善T2 DM患者的高血糖、胰岛素抵抗和间质液pH降低；2)间质液pH可能是影响淀粉样β蛋白积聚的关键因素之一。
The present study tried to clarify if mumefural would prevent hyperglycemia, one of the typical symptoms of type 2 diabetes mellitus (T2DM), since mumefural is an extract from Japanese apricots preventing hyperglycemia. To clarify if mumefural would prevent T2DM pathogenesis, we used Otsuka Long-Evans Tokushima fatty (OLETF) rats, T2DM model. Mumefural diminished hyperglycemia, HOMA-IR and plasma triglyceride concentration in OLETF rats under fasting conditions. In addition, mumefural elevated protein expression of sodium-coupled monocarboxylate transporter 1 (SMCT1) in the distal colon participating in absorption of weak organic acids, which behave as bases but not acids after absorption into the body. Mumefural also increased the interstitial fluid pH around the brain hippocampus lowered in OLETF rats compared with non-T2DM LETO rats used as control for OLETF rats. Amyloid-beta accumulation in the brain decreased in accordance with the pH elevation. On the one hand, mumefural didn't affect plasma concentrations of glucagon, GLP-1, GIP or PYY under fasting conditions. Taken together, these observations indicate that: 1) mumefural would be a useful functional food improving hyperglycemia, insulin resistance and the lowered interstitial fluid pH in T2DM; 2) the interstitial fluid pH would be one of key factors influencing the accumulation of amyloid-beta.