AMOP, a protein module aternativelly spliced in cancer cells
AMOP, a protein module aternativelly spliced in cancer cells
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DOI：
10.1016/s0968-0004(01)02049-7
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发表时间：
2002-03-01
影响因子：
13.8
通讯作者：
Bork, P
中科院分区：
文献类型：
--
作者：
Ciccarelli, FD;Doerks, T;Bork, P
本文描述了一种新的胞外结构域-AMOP，用于MUC4和其他蛋白质中的黏附相关结构域。这个结构域存在于假定的细胞黏附分子和MUC4的一些剪接变体中。MUC4剪接变异体在几种肿瘤中高表达；尤其是在胰腺癌中高表达，但在正常胰腺中不表达。AMOP在细胞黏附分子中的存在可能表明该结构域在黏附中的作用。
This article describes a new extracellular domain-AMOP for adhesion-associated domain in MUC4 and other proteins. This domain occurs in putative cell adhesion molecules and in some splice variants of MUC4. MUC4 splice variants are overexpressed in several tumours; in particular, they are highly expressed in pancreatic carcinomas but not in normal pancreas. The presence of AMOP in cell adhesion molecules could be indicative of a role for this domain in adhesion.