Variation at the angiotensin-converting enzyme gene and angiotensinogen gene loci in relation to blood pressure
Variation at the angiotensin-converting enzyme gene and angiotensinogen gene loci in relation to blood pressure
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DOI：
10.1161/01.hyp.28.6.1070
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发表时间：
1996-12-01
期刊：
影响因子：
8.3
通讯作者：
Savolainen, MJ
中科院分区：
文献类型：
--
作者：
Kiema, TR;Kauma, H;Savolainen, MJ
为了探讨血管紧张素转换酶和血管紧张素原基因多态性是否与高血压相关，我们对从社会保险机构登记中随机抽取的508名高血压受试者和523名对照受试者进行了病例对照研究。这些队列的特征和年龄和性别相匹配。采用聚合酶链式反应技术测定血管紧张素转换酶基因的插入/缺失多态性以及血管紧张素原基因第235位的甲硫氨酸→苏氨酸变体。两种多态性的等位基因频率和基因型分布在高血压和对照受试者中相似。根据年龄、体重指数和饮酒量调整后的收缩压和舒张压在血管紧张素转换酶和血管紧张素原基因的不同基因型之间没有显着差异。血管紧张素原和血管紧张素转换酶基因的变异对血压水平没有任何统计学上显着的协同效应。总之，肾素-血管紧张素级联基因的多态性不会显着增加这一中年人群患高血压的风险。
To investigate whether the polymorphisms in the angiotensin-converting enzyme and angiotensinogen genes are associated with hypertension, we carried out a case-control study of 508 hypertensive and 523 control subjects randomly selected from the Social Insurance Institution register. The cohorts were well characterized and matched for age and sex. The insertion/deletion polymorphism of the angiotensin-converting enzyme gene and the methionine --> threonine variant at position 235 of the angiotensinogen gene were determined by the polymerase chain reaction technique. The allele frequencies and genotype distributions of both polymorphisms were similar in hypertensive and control subjects. Systolic and diastolic pressures adjusted for age, body mass index, and alcohol consumption did not differ significantly between the different genotypes of the angiotensin-converting enzyme and angiotensinogen genes. The variation at the angiotensinogen and angiotensin-converting enzyme genes did not have any statistically significant synergistic effect on blood pressure levels. In conclusion, the polymorphisms in the renin-angiotensin cascade genes do not confer a significantly increased risk for the development of hypertension in this middle-aged, population-based cohort.