Three-Dimensional Model of Electroretinogram Field Potentials in the Rat Eye.
Three-Dimensional Model of Electroretinogram Field Potentials in the Rat Eye.
复制标题
大鼠眼视网膜电图场电位的三维模型。
DOI：
10.1109/tbme.2018.2816591
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Hetling,JohnR
中科院分区：
文献类型：
--
作者：
Selner,AshleyN;Derafshi,Zahra;Kunzer,BrianE;Hetling,JohnR
视网膜电图（ERG）的信息，特别是关于视网膜功能障碍或治疗救援的局部区域，可以通过增加对局部视网膜电流源和角膜测量的局部ERG电位之间关系的理解来增强。在这个方向上的一个关键步骤是一个强大的生物电场模型的ERG.MethodsA有限元模型的发展，以模拟ERG电位在角膜生理相关的transretinal电流。对大鼠眼睛的磁共振图像进行分割以定义所有主要的眼部结构，从文献中为组织分配电导率值。该模型进行了优化，以多电极ERG（meERG）记录在健康大鼠的眼睛的数据，并验证与meERG数据从眼睛与实验性病变在周边retina. Resultsafter优化，角膜电位的模拟分布是在良好的协议与测量值;残差是可比的平均差异从测量的平均值的个别眼睛。该模型预测的角膜电位分布为8只眼睛与实验病变具有类似的准确性，和一个测量的前到后病变的角膜电位分布的变化是很好的相关性与locationofthe lesion.ConclusionAn眼模型具有高的解剖精度成功地验证了一个强大的dataset.SignificanceThis模型现在可以用于ERG电极设计的优化，以及通过求解逆生物电源问题来支持来自meERG数据的视网膜的功能映射。
ObjectiveThe information derived from the electroretinogram (ERG), especially with regard to local areas of retinal dysfunction or therapeutic rescue, can be enhanced by an increased understanding of the relationship between local retinal current sources and local ERG potentials measured at the cornea. A critical step in this direction is the development of a robust bioelectric field model of the ERG.MethodsA finite-element model was created to simulate ERG potentials at the cornea resulting from physiologically relevant transretinal currents. A magnetic resonance image of a rat eye was segmented to define all major ocular structures, tissues were assigned conductivity values from the literature. The model was optimized to multi-electrode ERG (meERG) data recorded in healthy rat eyes, and validated with meERG data from eyes with experimental lesions in peripheral retina.ResultsFollowing optimization, the simulated distribution of corneal potentials was in good agreement with measured values; residual error was comparable to the average difference of individual eyes from the measured mean. The model predicted the corneal potential distribution for eight eyes with experimental lesions with similar accuracy, and a measure of pre- to post-lesion changes in corneal potential distribution was well correlated with the location of the lesion.ConclusionAn eye model with high anatomical accuracy was successfully validated against a robust dataset.SignificanceThis model can now be used for optimization of ERG electrode design, and to support functional mapping of the retina from meERG data via solving the inverse bioelectric source problem.