Human dorsal and ventral auditory streams subserve rehearsal-based and echoic processes during verbal working memory
Human dorsal and ventral auditory streams subserve rehearsal-based and echoic processes during verbal working memory
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DOI：
10.1016/j.neuron.2005.09.029
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发表时间：
2005-11-23
期刊：
影响因子：
16.2
通讯作者：
Berman, KF
中科院分区：
文献类型：
--
作者：
Buchsbaum, BR;Olsen, RK;Berman, KF
听到一系列单词并重复它们需要感觉运动处理和一些更临时的存储。我们研究了言语记忆的神经机制，通过使用功能磁共振成像和任务，旨在梳理除了感知为基础的（“回声”）记忆从语音发音记忆。两个或三个词对的集合呈现双峰，随后是一个提示，指示从哪个模态（听觉或视觉）项目被检索和排练超过延迟。虽然在颞平面（PT）的延迟期激活是不敏感的源模态，并显示持续的延迟期活动，上级颞回（STG）激活更有力时，检索项目已到达听觉模态，并显示短暂的延迟期活动。功能连接分析发现两个地形不同的额颞电路，与STG coactivating更强烈的腹外侧前额叶皮层和PT coactivating更强烈的背外侧前额叶皮层。这些主张腹侧和背侧听觉流在言语工作记忆中的独立贡献。
To hear a sequence of words and repeat them requires sensory-motor processing and something more-temporary storage. We investigated neural mechanisms of verbal memory by using fMRI and a task designed to tease apart perceptually based ("echoic") memory from phonological-articulatory memory. Sets of two- or three-word pairs were presented bimodally, followed by a cue indicating from which modality (auditory or visual) items were to be retrieved and rehearsed over a delay. Although delay-period activation in the planum temporale (PT) was insensible to the source modality and showed sustained delay-period activity, the superior temporal gyrus (STG) activated more vigorously when the retrieved items had arrived to the auditory modality and showed transient delay-period activity. Functional connectivity analysis revealed two topographically distinct fronto-temporal circuits, with STG coactivating more strongly with ventrolateral prefrontal cortex and PT coactivating more strongly with dorsolateral prefrontal cortex. These argue for separate contributions of ventral and dorsal auditory streams in verbal working memory.