A vitamin A analogue inhibits radiation-induced oncogenic transformation
A vitamin A analogue inhibits radiation-induced oncogenic transformation
复制标题
维生素 A 类似物抑制辐射诱导的致癌转化
作者：
L. Harisiadis;Richard C. Miller;E. Hall;C. Borek
维生素A及其类似物（类维生素A）预防化学诱导肿瘤的能力已在各种实验系统中进行了研究1。我们在这里研究的可能性，维甲酸也可能抑制辐射诱导的致癌转化使用C3 H小鼠胚胎成纤维细胞培养的细胞系。我们报告了使用一种这样的化合物Ro-11-1430显著降低了转化频率，其合成和结构已由Bollag 2描述。
The ability of vitamin A and its analogues (retinoids) to prevent chemically-induced tumours has been studied in various experimental systems1. We have investigated here the possibility that retinoids might also inhibit radiation-induced oncogenic transformation using a cell line of C3H mouse embryo fibroblasts grown in culture. We report a marked reduction in the transformation frequency by using one such compound, Ro-11-1430, the synthesis and structure of which has been described by Bollag2.