Viral channel-forming proteins.
Viral channel-forming proteins.
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DOI：
10.1016/s1937-6448(09)75002-6
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发表时间：
2009
影响因子：
--
通讯作者：
Krüger J
中科院分区：
文献类型：
--
作者：
Fischer WB;Krüger J
在许多病毒基因组中发现了成簇蛋白。在某些情况下，它们在病毒生命周期中的作用已经很好地理解，在某些情况下，它仍然需要阐明。一个共同的主题是它们的作用模式涉及脂质膜上电化学或质子梯度的变化，这调节了病毒或细胞活性。阻断这些蛋白质可能是一种合适的治疗策略，因为对于某些病毒来说，这可能是“致命的”。除了许多生物学相关的问题仍有待回答，也有许多悬而未决的问题，涉及生物物理方面以及结构信息和分子水平上的功能机制。讨论了不可忽视的生物物理问题，并总结了该领域的工作。
Channel-forming proteins are found in a number of viral genomes. In some cases, their role in the viral life cycle is well understood, in some cases it needs still to be elucidated. A common theme is that their mode of action involves a change of electrochemical or proton gradient across the lipid membrane which modulates the viral or cellular activity. Blocking these proteins can be a suitable therapeutic strategy as for some viruses this may be “lethal.” Besides the many biological relevant questions still to be answered, there are also many open questions concerning the biophysical side as well as structural information and the mechanism of function on a molecular level. The immanent biophysical issues are addressed and the work in the field is summarized.