Association Between Periodontal Disease and Prostate-Specific Antigen Levels in Chronic Prostatitis Patients
Association Between Periodontal Disease and Prostate-Specific Antigen Levels in Chronic Prostatitis Patients
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DOI：
10.1902/jop.2010.090646
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发表时间：
2010-06-01
影响因子：
4.3
通讯作者：
Skillicorn, Robert
中科院分区：
文献类型：
--
作者：
Joshi, Nishant;Bissada, Nabil F.;Skillicorn, Robert
背景：前列腺特异性抗原（PSA）是由前列腺腺泡上皮细胞产生的炎症标志物。在存在前列腺炎症或恶性肿瘤的情况下，PSA水平>= 4 ng/ml。本研究旨在探讨慢性前列腺炎患者牙周炎与PSA水平之间的关系。方法：35例因直肠指检异常或PSA升高而接受前列腺活检的受试者参加本研究。测定菌斑和牙龈指数、探诊出血、探诊深度和临床附着水平（CAL）。双侧独立样本t检验评估前列腺炎和牙周炎组之间PSA水平的任何显着差异。结果：平均PSA水平显着高于（P = 0.04）在中度/重度前列腺炎症的受试者比那些没有/轻度（8.8 +/- 5.8与5.7 +/- 3.1 ng/ml）。CAL mm受试者的PSA水平高于CAL = 2.7 mm受试者，但无统计学意义（10.8 +/- 7 ng/ml）的平均PSA水平显著较高（P = 0.05）（5.6 +/- 3.7 ng/ml），也不是仅CAL >= 2.7 mm（5.7 +/- 2.4 ng/ml）或中度/重度前列腺炎（6 +/- 1.9 ng/ml）。患有CAL mm和中度/重度前列腺炎共病的受试者的PSA水平高于仅患有任一疾病的受试者。牙周病学杂志2010;81：864-869。
Background: Prostate-specific antigen (PSA) is an inflammatory marker produced by the epithelial cells of the prostate acini. In the presence of inflammation or malignancy of the prostate, PSA levels are >= 4 ng/ml. This preliminary study was conducted to evaluate any association between periodontitis and PSA levels in chronic prostatitis patients.Methods: Thirty-five subjects who underwent prostate biopsy because of abnormal findings on digital rectal examination or elevated PSA ng/ml) participated in the study. Plaque and gingival indices, bleeding on probing, probing depth, and clinical attachment level (CAL) were determined. Two-sided independent sample t tests assessed any significant differences in the PSA levels between and among the groups of prostatitis and periodontitis.Results: Mean PSA levels were significantly higher (P = 0.04) in subjects with moderate/severe prostate inflammation than those with none/mild (8.8 +/- 5.8 versus 5.7 +/- 3.1 ng/ml). Subjects with CAL mm had higher but not statistically significant PSA levels than those with CAL = 2.7 mm (10.8 +/- 7 ng/ml) had significantly higher mean PSA levels (P = 0.05) than those with neither condition (5.6 +/- 3.7 ng/ml) nor only CAL >= 2.7 mm (5.7 +/- 2.4 ng/ml) or moderate/severe prostatitis (6 +/- 1.9 ng/ml).Conclusion: Subjects having comorbidity of CAL mm and moderate/severe prostatitis have higher PSA levels than those with either condition alone. J Periodontol 2010;81:864-869.