In vivo spectral domain optical coherence tomography volumetric imaging and spectral Doppler velocimetry of early stage embryonic chicken heart development
In vivo spectral domain optical coherence tomography volumetric imaging and spectral Doppler velocimetry of early stage embryonic chicken heart development
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DOI：
10.1364/josaa.25.003134
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发表时间：
2008-12-01
影响因子：
1.9
通讯作者：
Izatt, J. A.
中科院分区：
文献类型：
--
作者：
Davis, A. M.;Rothenberg, F. G.;Izatt, J. A.
由于无法成像胚胎心脏结构并同时测量活体血流动力学，阻碍了理解胚胎心脏发育的进展。我们开发了一套光谱域光学相干层析成像系统，用于活体鸡胚心脏的体积成像。我们还开发了一种称为频谱多普勒测速(SDV)的技术，用于定量测量血流动力学。我们将登台亮相。胚胎心脏从最初的管子形成到同一胚胎的心内膜垫发育的几个发育阶段的活体体积图像。SDV测量揭示了心管结构对血流动力学的影响。(C)2008年美国光学学会
Progress toward understanding embryonic heart development has been hampered by the inability to image embryonic heart structure and Simultaneously measure blood flow dynamics in vivo. We have developed a spectral domain optical coherence tomography system for in vivo volumetric imaging of the chicken embryo heart. We have also developed a technique called spectral Doppler velocimetry (SDV) for quantitative measurement of blood flow dynamics. We present in. vivo volume images of the embryonic heart from initial tube formation to development of endocardial cushions of the same embryo over several stages of development. SDV measurements reveal the influence of heart tube structure on blood flow dynamics. (C) 2008 Optical Society of America