Immunohistochemical Observation of Notch Signaling in a Case of Calcifying Cystic Odontogenic Tumor
Immunohistochemical Observation of Notch Signaling in a Case of Calcifying Cystic Odontogenic Tumor
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DOI：
10.2485/jhtb.19.147
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发表时间：
2010-12-01
影响因子：
0.4
通讯作者：
Kawakami, Toshiyuki
中科院分区：
文献类型：
--
作者：
Nakano, Keisuke;Siar, Chong Huat;Kawakami, Toshiyuki
牙发生是一个复杂的生物学过程，既有上皮细胞的参与，也有间充质细胞的参与，这一过程直接反映了牙源性肿瘤的发生发展。因此，我们检测了一例钙化性囊性牙源性肿瘤中的Notch信号，并以成釉细胞纤维瘤和牙源性粘液瘤病例作为对照。在这些标本中，Notch阳性产物存在于钙化囊性牙源性肿瘤和成釉细胞纤维瘤病例的上皮和外胚间充质成分中，但在牙源性粘液瘤病例中为阴性，IHC和ISH检查没有牙源性上皮岛。因此，Notch信号通路在牙源性上皮和牙源性外胚间充质组织的细胞分化或组织特异性的获得中起重要作用。
Odontogenesis is a complex biological process both with epithelial and mesenchymal tissues, and this process directly reflects the development of odontogenic neoplasms. Therefore, we have examined Notch signaling in a case of calcifying cystic odontogenic tumor, with ameloblastic fibroma and odontogenic myxoma cases as controls. In these specimens, Notch-positive-products were present both in the epithelial and ectomesenchymal components in the calcifying cystic odontogenic tumor and the ameloblastic fibroma case, but negative in the odontogenic myxoma case, having no odontogenic epithelial islands to IHC and ISH examinations. Therefore, the examination results suggest that Notch signaling plays some important roles in cytological differentiation or acquisition of tissue-specific characteristics between odontogenic epithelium and odontogenic ectomesenchymal tissues.