EXPERIMENTAL PANCREATITIS IN THE RAT - SODIUM TAUROCHOLATE-INDUCED ACUTE HEMORRHAGIC-PANCREATITIS
EXPERIMENTAL PANCREATITIS IN THE RAT - SODIUM TAUROCHOLATE-INDUCED ACUTE HEMORRHAGIC-PANCREATITIS
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DOI：
10.3109/00365528009181493
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发表时间：
1980-01-01
影响因子：
1.9
通讯作者：
NEVALAINEN, TJ
中科院分区：
文献类型：
--
作者：
AHO, HJ;KOSKENSALO, SML;NEVALAINEN, TJ
Sodium taurocholate injected into the pancreatic duct system of the rat caused acute hemorrhagic pancreatitis. The pancreatic lesions were immediate and characterized by interstitial edema, extensive necrotic changes of the acinar cells and hemorrhages during the first 24 h after the injection. In animals surviving 72 h there were marked acinar atrophy and pancreatic fibrosis. The mortality increased according to the amount of sodium taurocholate injected. Except for necrosis of occasional liver cells, other organs examined were histologically normal. An experimental model for studying the pathogenesis of acute pancreatitis was created. Bile can apparently initiate acute hemorrhagic pancreatitis.
