Association of Acromegaly and Central Sleep Apnea Syndrome
Association of Acromegaly and Central Sleep Apnea Syndrome
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DOI：
10.5152/turkthoracj.2017.17003
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发表时间：
2019-04-01
影响因子：
0.9
通讯作者：
Gokce, Erkan
中科院分区：
文献类型：
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作者：
Pazarli, Ahmet Cemal;Koseoglu, Handan Inonu;Gokce, Erkan
肢端肥大症通常以功能性垂体腺瘤引起的骺斑闭合后生长激素（GH）过度分泌为特征。肢端肥大症最常见的表现是肢端和软组织过度生长、糖尿病、高血压、心脏和呼吸衰竭。在患者中，由于舌头增大和喉部组织增厚，可能会发生上呼吸道阻塞;因此，阻塞性睡眠呼吸暂停综合征（OSAS）通常发生在肢端肥大症中。先前的研究表明肢端肥大症和中枢性睡眠呼吸暂停综合征（CSAS）之间存在关联。其中一些描述的患者显示GH水平升高可能导致呼吸驱动缺陷。肢端肥大症中出现的大多数系统性疾病需要有效的治疗。我们认为，有必要通过检查睡眠中的呼吸障碍来进行有效的治疗。
Acromegaly is usually characterized by the excessive secretion of growth hormone (GH) after the closure of epiphyseal plaques, resulting from functional pituitary adenomas. The most common manifestations of acromegaly are acral and soft tissue overgrowth, diabetes mellitus, hypertension, and heart and respiratory failure. In patients, obstruction of the upper airway may develop due to enlargement of the tongue and thickening of the tissues of the larynx; consequently, obstructive sleep apnea syndrome (OSAS) occurs commonly in acromegaly. Previous studies have shown an association between acromegaly and central sleep apnea syndrome (CSAS). Some of these described patients described showed that an elevation in the GH level may cause a defect in the respiratory drive. Most systemic diseases seen in acromegaly require effective treatment. We believe that it is necessary to perform effective treatments by examining respiratory disorders in sleep.