Plasma levels of polychlorinated biphenyls and risk of cutaneous malignant melanoma: a preliminary study
Plasma levels of polychlorinated biphenyls and risk of cutaneous malignant melanoma: a preliminary study
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DOI：
10.1002/ijc.25503
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发表时间：
2011-04-15
影响因子：
6.4
通讯作者：
Spinelli, John J.
中科院分区：
文献类型：
--
作者：
Gallagher, Richard P.;MacArthur, Amy C.;Spinelli, John J.
许多流行病学研究表明，接触多氯联苯（PCB）和其他有机氯化合物（OCC）会增加皮肤恶性黑色素瘤（CMM）的风险。然而，这些研究通常没有OCC暴露的生物测量，并且无法控制日光暴露，这是这种疾病的主要已知环境风险因素。这项初步研究探讨了OCC残留量之间的关系，血浆和风险的CMM调整阳光敏感性和阳光照射。对80例CMM患者和310例对照者进行了病例对照研究。收集了一生的阳光暴露信息，沿着色素沉着变量和阳光敏感性数据，沿着血液样本。采用气相色谱法测定了病例和对照组血浆中14种多氯联苯同系物和11种有机氯农药残留量。CMM的风险和非二恶英样多氯联苯（调整后的OR 5 7.02; 95% CI：2.30-21.43的最高四分位数）和几个PCB同系物，有机氯农药或代谢物的血浆水平之间存在很强的关联。在控制了阳光敏感性和阳光照射后，这些关联仍然存在。这项研究的结果需要在更大规模的研究中进行独立确认。然而，他们认为除了紫外线辐射之外的环境因素可能在CMM的发生中发挥作用，并表明寻找可能增加风险的其他因素可能是富有成效的。流行病学
A number of epidemiologic studies have suggested that exposure to polychlorinated biphenyls (PCB) and other organochlorine compounds (OCC) increase risk of cutaneous malignant melanoma (CMM). However, these studies have generally had no biologic measure of OCC exposure, and have been unable to control for sun exposure, the major known environmental risk factor for this disease. This preliminary study examined the relationship between OCC residues in plasma and risk of CMM adjusting for sun sensitivity and sun exposure. A case-control study of 80 CMM patients and 310 control subjects was conducted. Lifetime sun exposure information, along with data on pigmentation variables and sun sensitivity data was collected, along with a blood sample. Cases and controls were assayed for plasma levels of 14 PCB congeners and 11 organochlorine pesticide residues using gas chromatography. Strong associations were seen between risk of CMM and plasma levels of non-dioxin-like PCBs (Adjusted OR 5 7.02; 95% CI: 2.30-21.43 for highest quartile) and several PCB congeners, organochlorine pesticides or metabolites. These associations persisted after control for sun sensitivity and sun exposure. Results from this investigation require independent confirmation in larger studies. However, they suggest that environmental factors other than UV radiation may play a role in genesis of CMM, and indicate that it may be productive to search for further agents which might increase risk. Epidemiology